Can SARs-CoV-2 Infect Nasal Epithelium and Cause Parkinson's Disease?
*Corresponding Author: Mohsen Rafie, Department of Clinical Psychology, University of Semnan, Semnan, Iran, Email: rafiemohsen05@gmail.comReceived Date: Jan 02, 2023 / Published Date: Jan 31, 2023
Citation: Rafie M, Azadmehr F, Taheri M, Mansouri A, Naeim VM (2023) Can SARs-CoV-2 Infect Nasal Epithelium and Cause Parkinson's Disease?. J Alzheimers Dis Parkinsonism 13:560.DOI: 10.4172/2161-0460.1000560
Copyright: © 2023 Rafie M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract
Background: The main trigger for Parkinson's disease is a mutated version of a protein called alpha-synuclein. This protein accumulates in dopamine-producing neurons. COVID-19 can increase the risk of Parkinson's and other neurological diseases.
Materials and Methods: This research study was conducted by the library method.
Results: The results showed that the virus can cause neuroinflammation, which, as a predisposing event, predisposes the brain to overreaction to subsequent neurological events. This secondary neurological event can be anything from another viral infection to poisoning and even aging. A secondary neurological event triggers an abnormal brain response that leads to nerve degeneration and eventually Parkinson's disease. The results show that the SARS-CoV-2 virus as a neurotropic virus can enter brain tissue.
Conclusion: Therefore, the virus certainly has the potential to act as a predisposing event in increasing the risk of Parkinson's disease.