Abstract

Telomeres, the protective caps at the ends of chromosomes, and ribosome biogenesis, the intricate process of ribosome assembly, are fundamental to cellular function and health. While traditionally studied in isolation, emerging research indicates a complex interplay between these two essential cellular processes. Telomere length maintenance influences ribosome biogenesis, and conversely, ribosomal proteins have been implicated in telomere regulation. This review explores the primary and useful interconnections between telomere science and ribosome biogenesis, highlighting their roles in cellular homeostasis and disease. We discuss the molecular mechanisms underlying their crosstalk and its implications for aging, cancer, and other age-related disorders. Furthermore, we explore the therapeutic potential of targeting this nexus for intervention strategies aimed at promoting healthy aging and combating diseases associated with cellular dysfunction. Through an integrated understanding of telomere biology and ribosome biogenesis, novel therapeutic avenues may be unveiled, offering promise for enhancing human health and longevity.