Abstract

This study investigates the relationship between bone marrow lesions (BMLs), joint effusion, and weight-bearing pain in individuals with knee osteoarthritis (OA). Utilizing a cohort of patients diagnosed with knee OA, we assessed the presence of BMLs and joint effusion through magnetic resonance imaging (MRI) and evaluated pain intensity during weight-bearing activities using standardized pain scales. Our findings reveal that both BMLs and joint effusion are significantly associated with increased weight-bearing pain, independently of other clinical factors. The presence of BMLs was correlated with higher pain scores, while joint effusion contributed to pain severity. These results underscore the importance of addressing both BMLs and joint effusion in the clinical management of knee OA, suggesting that targeted interventions may help alleviate pain and improve patient outcomes. Further research is needed to explore the underlying mechanisms and potential therapeutic strategies.