Abstract

The blood-brain barrier (BBB) restricts the passage of therapeutic agents into the brain, posing a significant challenge for treating neurological disorders. This review explores biopharmaceutical strategies aimed at overcoming BBB limitations to enhance drug delivery. Nanoparticle-based systems, receptor-mediated transport, focused ultrasound, peptide vectorization, and prodrug strategies are discussed as promising approaches to facilitate effective drug penetration into the brain. These strategies offer potential solutions to improve treatment outcomes for conditions such as Alzheimer's disease, Parkinson's disease, and brain tumors.