Abstract

The delivery of poorly soluble drugs through oral administration presents substantial challenges in attaining sufficient bioavailability and therapeutic efficacy. To address these issues, biodegradable polymer nanoparticles have emerged as promising carriers. These nanoparticles enhance the solubility, stability, and absorption of poorly soluble drugs. This article reviews recent advancements in the use of biodegradable polymer nanoparticles to improve oral bioavailability. It focuses on design strategies, such as surface modification and particle size optimization, and explores the mechanisms of drug delivery, including enhanced intestinal permeability and prolonged circulation time. Furthermore, the review discusses future prospects in pharmaceutical applications, highlighting the potential for these nanoparticles to revolutionize the delivery and effectiveness of oral medications.