Bioavailability Enhancement Strategies in Biopharmaceutics
*Corresponding Author:Received Date: Jun 04, 2024 / Published Date: Jun 28, 2024
Copyright: © 0 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
![image](https://www.omicsonline.org/images/download-pdf.jpg)
Abstract
Abstract: Bioavailability is a crucial determinant in the efficacy of pharmaceuticals, dictating the proportion of an administered drug that enters systemic circulation. Enhancing bioavailability is essential, particularly for drugs with low solubility and permeability. This article reviews various strategies to improve bioavailability, including formulation approaches, chemical modifications, permeability enhancers, and metabolic inhibitors. Techniques such as solid dispersions, lipidbased formulations, nanotechnology, and cyclodextrin complexes are discussed for their roles in enhancing solubility and absorption. Chemical modifications like prodrugs and salt formations, along with permeability enhancers and enzyme inhibitors, are also explored. By employing these strategies, the pharmaceutical industry can develop more effective therapeutics with improved patient outcomes