JBR Journal of Interdisciplinary Medicine and Dental Science
Open Access

Research Article

Bioactive-Functionalized Interpenetrating Network Hydrogel (BIOF-IPN): A Novel Biomaterial Transforming the Mechanism of Bio-Repair, Bio-Adhesion and Therapeutic Capability – An In Vitro Study

Tamara Perchyonok V^1*, Vanessa Reher², Sias Grobler³, Annette Oliver³ and Shengmiao Zhang⁴

¹Research and Development Department, VTPCHEM PTY LTD., Southport 4215, Australia

²School of Dentistry and Oral Health, Gold Coast campus, Griffith University, QLD 4222, Australia

³Oral and Dental Research Institute, Faculty of Dentistry, University of the Western Cape, Private Bag X1, Tygerberg 7505, Cape Town, South Africa

⁴School of Material Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

Corresponding Author:

Tamara Perchyonok V
Research and Development Department
VTPCHEM PTY LTD., Southport 4215, Australia
Tel: +61-414-596-304
Email: tamaraperchyonok@gmail.com

Received Date: December 16, 2014; Accepted Date: January 24, 2015; Published Date: January 27, 2015

Citation: Tamara Perchyonok V, Vanessa Reher, Sias Grobler, Annette Oliver, Shengmiao Zhang (2015) Bioactive-Functionalized Interpenetrating Network Hydrogel (BIOF-IPN): A Novel Biomaterial Transforming the Mechanism of Bio-Repair, Bio-Adhesion and Therapeutic Capability – An In Vitro Study. J Interdiscipl Med Dent Sci 3:166. doi: 10.4172/2376-032X.1000166

Copyright: © 2015 Perchyonok VT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The purpose of this investigation was to evaluate and report the in vitro performance of a few selected Bioactive- Functionalized Interpenetrating Network Hydrogels (BIOF-IPN); a novel biomaterial with a build-in mechanism of biorepair capacity, bio-adhesion and therapeutic capability. The study also evaluates the cytotoxicity of the newly developed material, and its ability to be used in the dental field. In this study, four bioactive-functionalized interpenetrating network hydrogels (BIOF-IPN) were prepared by dispersion of different therapeutic agents. The dentin bond strength is tested, the bio-adhesivity, modulus of elasticity and cytotoxicity of the materials were investigated, and the performance of the therapeutic-agents release profile, evaluated. The gels used in this study demonstrated excellent capacity in leading to high internal surface areas with low diffusional resistance. An increase in bond strength of the dentin treated with the BIOF-IPNs compared to the bond strength of the conventionally bonded teeth was indicated, and a significant increase in the modulus of elasticity observed. BIOF-INPs showed high adhesive force promotes binding to the negative surface of skin or dentin structure. It was found that chitosan alone increased the cell survival rate remarkably (113%) and its presence with naproxen and ibuprofen increased the cell survival rate [naproxen (93%), chitosan/naproxen (96.6%), ibuprofen (76.6%), and chitosan/ibuprofen (89.1%). The use of BIOF-IPNs has increased the time of the release of therapeutic agents, and protected the active ingredient from any type of free radical damage produced in and around the active site. Present results demonstrate the capability of the BIOF-IPNs to play an important role in the defense mechanism, and in the functional multidimensional restorative repair materials. The findings suggest that the new material would definitely find applications in functional dental composites and regenerative dentistry.

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