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Hindi Bevacizumab (Bmab) +Dihydropyrimidine Dehydrogenase (DPD) Inhibitory Fluor pyrimidine (DIF) Combined Chemotherapy for the Treatment of Late-Stage Elderly Patients with Advanced/Recurrent Colorectal Cancer (ARCC)
*Corresponding Author:
Copyright: © 2017 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Objective: In Japan, the elderly represent more than 20% of the total population. The incidence of elderly patients with advanced/recurrent colorectal cancer (ARCC) has also increased. However, the optimal regimen for elderly patients, particularly those over 75 years of age (advanced elderly), has not been established.
Results: The STD was 979 days, the median PFS was 350 days, and the RR was 23.3%. Grade ≥3 AEs with each regimen were: Bob + DIF, 1.9%, other regimens, 14.4%. Although no significant difference was observed in OS or PFS between Bmab + DIF and other treatment regimens, the transition rate to 2nd line chemotherapy after disease progression after first-line treatment was higher with Bmab + DIF (54.6% [6/11]) than with other treatment regimens (38.9% [7/18]); however, this difference did not reach statistical significance
