Journal of Alzheimers Disease & Parkinsonism
Open Access

Bettering of Learning Activity through Elevated P-Cresol Levels in the Brain: Insights from Active Avoidance Testing in Wistar Rats

Gigi Tevzadze^1* and Zaal Kikvidze²

¹Department of Sociology of Philosophy and Social Sciences, 4-D Research Institute, Ilia State University, Tbilisi, Georgia

²Department of Ethnobotany, Institute of Botany, Ilia State University, Tbilisi, Georgia

Received Date: May 01, 2024 / Published Date: Jun 03, 2024

Citation: Tevzadze G, Kikvidze Z (2024) Bettering of Learning Activity through Elevated P-Cresol Levels in the Brain: Insights from Active Avoidance Testing in Wistar Rats. J Alzheimers Dis Parkinsonism 14:600.DOI: 10.4172/2161-0460.1000600

Copyright: © 2024 Tevzadze G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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It is established that p-cresol, a compound produced by bacterial colonies within the gastrointestinal tract of mammals, plays a contributory role in the manifestation of various mental disorders. Recently, our research demonstrated that diminishing p-cresol levels in the brain adversely impact the behavioral manifestation of cognitive abilities in rats. In this study, we aimed to investigate the impact of augmenting p-cresol levels in the brain on learning. The Active Avoidance Test (AAT) was employed to assess learning capabilities. The results, with a high level of confidence, indicated that rats with an increased concentration of p-cresol in the brain exhibited superior task performance and accelerated learning compared to the control group.

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