ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Review Article   
  • J Alzheimers Dis Parkinsonism 2018, Vol 8(2): 431
  • DOI: 10.4172/2161-0460.1000431

Apathy in Huntington’s Disease: A Review of the Current Conceptualization

Marta Camacho1, Roger A Barker1,2 and Sarah L Mason1*
1John Van Geest Centre for Brain Repair, University of Cambridge, UK
2Department of Clinical Neuroscience, University of Cambridge, UK
*Corresponding Author : Sarah L Mason, John Van Geest Centre for Brain Repair Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK, Tel: +441223331160, Email: slm64@cam.ac.uk

Received Date: Feb 21, 2018 / Accepted Date: Mar 21, 2018 / Published Date: Mar 28, 2018

Abstract

Apathy is one of the most common psychiatric symptoms experienced by patients with Huntington’s disease (HD). It appears early, progresses with the disease course and has been shown to contribute significantly to caregiver burden. However, what is understood by apathy in HD is not clearly defined nor the underlying mechanisms responsible for it. In this review, we discuss the concept of apathy in the context of HD and propose that a consensus regarding its conceptualisation and subsequently its diagnostic criteria would significantly benefit the field. In order to undertake this work, we began by reviewing the existing literature on the definition and assessment of apathy in HD, its underlying neurobiological basis and its relationship to other related features such as abulia, anhedonia and alexithymia. In the context of HD, apathy could be described by a loss of or diminished motivation, emotion and goal-directed behaviour that is not best explained by motor or social constraints of the disease. However, there is an urgent need to better understand the characteristics of apathy specifically in HD, how they evolve across the disease course and how they relate to central dopaminergic pathways. Only by undertaking such work can we hope to better understand this early and disabling aspect of HD.

Keywords: Huntington’s disease; Apathy; Reward; Abolition; Anhedonia; Basal ganglia

Citation: Camacho M, Barker RA, Mason SL (2018) Apathy in Huntington’s Disease: A Review of the Current Conceptualization. J Alzheimers Dis Parkinsonism 8: 431. Doi: 10.4172/2161-0460.1000431

Copyright: ©2018 Camacho M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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