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Antiangiogenic Therapy: Issues and Expectations

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Copyright: © 2021  . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 
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Abstract

The understanding that angiogenesis is essential for tumor growth and metastasis formation has led to a large effort to discover effective antiangiogenic compounds. It should be perceived that angiogenesis happens in pathologic cycles as well as in homeostasis. Physiologic angiogenesis is significant in multiplication, wound healing, menses, and vascular diseases like coronary artery and peripheral vascular diseases. Thus, as always, a balance must be maintained between limiting angiogenesis to the tumor and causing significant toxicity to
the host.

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