Abstract

A new simple , accurate , rapid and precise isocratic , ( ultra-high performance liquid chromatography) ,( UHPLC ) method was developed and validated for determination of trazodone in bulk drug and tablet dosage form .analytical tech UV detector and column with 100 mm x 4.6 mm i.d . And 2.5 µm particle size methanol’s 60 with OPA (60: 40 v/v) PH were used as the mobile phase for the method. The detection wavelength was 249 mm and flow rate were 0.7ml/min .in the developed method. The retention time of trazodone were found to be 4.641 min .the method was validated according to the regulatory guidelines with respect to specificity, precision, accuracy, linearity, and robustness, etc