Abstract

A biocompatible and biodegradable poly (1,4-butylene succinate) microfibrous tubular scaffold has been produced through the use of electrospinning.The scaffold’s morphology was N-optimized to prevent cell infiltration through the graft’s wall and to promote cell integration, adhesion, and growth as a micro-porous conduit with a small diameter.The scaffold’s mechanical properties and morphology were examined and compared to those of native conduits.Scaffolds were then seeded with adult normal human dermal fibroblasts to test cytocompatibility in vitro.The hemolytic effect was assessed following incubation with whole blood that had been diluted.The graft is able to provide initial mechanical support and functionality thanks to the demonstrated degradation profile during colonization and subsequent replacement by host cells. Elastic modulus (less than 17.5 1.6 MPa), ultimate tensile stress (less than 3.95 0.17 MPa), strain to failure (less than 57 4.5%), and suture retention force (less than 2.65 0.32 N) were all within the physiological range for tubular conduits. There was no delamination of the scaffold’s mechanical properties.This combination of properties may make it possible to use PBS as a biomaterial to create scaffolds that support host cell remodelling and provide structure and function over time.