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Hindi Research Article
Analgesic and CNS Depressant Effect of the Crude Ethanolic Extract of the Operculina turpethum
Mohammad Nazrul Islam1*, Mohammad Abu Bin Nyeem1, Mohammad Abu Taher1 and Abdul Awal2
1Department of Unani Medicine, Hamdard University Bangladesh, Narayanganj-1440, Bangladesh
2Department of Pharmacology, Bangladesh Agricultural University, Bangladesh
- Corresponding Author:
- Islam MdN
Assistant Professor
Hamdard University
Unani Medicine, Newtown
Sonargaon, Narayanganj
Dhaka, 1440, Bangladesh
Tel: 008801732780912
E-mail: dr_sayemnazrul@yahoo.com
Received date: October 18, 2015; Accepted date: November 26, 2015; Published date: November 28, 2015
Citation: Islam MN, Nyeem MAB, Taher MA, Awal A (2015) Analgesic and CNS Depressant Effect of the Crude Ethanolic Extract of the Operculina turpethum. Biosens J 4:132. doi:10.4172/2090-4967.1000132
Copyright: © 2015 Islam MN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The Operculina turpethum (Fam. Convolvulaceae) is a traditional medicinal plant for the treatment of anthelmintic, expectorant, antipyretic, anti-inflammatory and purgative. The work reached the acute toxicity of Operculina turpethum and its action on the ethanolic extract of the central nervous system (CNS) because on data in the literature have been found of pharmacological activity of this plant in the CNS. The Operculina turpethum was extracted with ethanol and investigated for its CNS activity of experimental model in mice. The extract produce a dose dependent reduction of the onset and duration of pentobarbitone induced hypnosis, reduction of locomotor and exploratory activities in the open field, hole cross at the dose level of 250 mg/kg and 500 mg/kg body weight. At the same dose labels, the extract dose dependently inhibited acetic acid induced writhing in mice. This study suggested that the extract possess CNS depressant activity.
