Abstract

The name of the motor neuron disease with the highest prevalence is amyotrophic lateral sclerosis (ALS). It usually has adult-onset degeneration of the upper and lower motor neurons and results in mortality a few years after beginning. Several of the known mutant genes present in familial cases of the disease have also been detected in sporadic forms of the disease. A percentage of ALS patients have an inherited form of the disease. The many ALS-linked gene products, which affect the disease's course and diminish voluntary motor capacity, are not completely understood. This review explores the important developments in our understanding of the disease's underlying underpinnings, which could someday result in new therapeutic choices.