Journal of Gastrointestinal & Digestive System
Open Access

Mini Review

Amyloid Goiter Complicated with Inflammatory Bowel Disease: Literature Review

Toru Shizuma^*

Department of Physiology, School of Medicine, Tokai University, 143, Shimokasuya, Isehara, Kanagawa, Japan

*Corresponding Author:

Toru Shizuma
Department of Physiology
School of Medicine, Tokai University
143, Shimokasuya, Isehara
Kanagawa, Japan
Tel: +81-0463-93-1121
E-mail: shizuma@is.icc.u-tokai.ac.jp

Received date: July 24, 2015 Accepted date: September 01, 2015 Published date: September 06, 2015

Citation: Shizuma T (2015) Amyloid Goiter Complicated with Inflammatory Bowel Disease: Literature. J Gastrointest Dig Syst 5:333. doi:10.4172/2161-069X.1000333

Copyright: © 2015 Shizuma T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Amyloid goiter (AG) is an uncommon complication of inflammatory bowel disease (IBD). Here a literature review of cases of AG developed as a complication in IBD patients was conducted. Among 13 reviewed cases (12 of Crohn’s disease and one of ulcerative colitis), AG was diagnosed between the ages of 26 and 58 years. Among these cases, thyroid function was investigated in 12, of which eight showed thyroid function within the normal range, three demonstrated hypothyroidism, and one showed subclinical hypothyroidism. There were no obvious correlations between the development of AG and activity or flare up of IBD. Six of the thirteen cases were complicated with renal failure or nephrotic syndrome due to renal amyloidosis, and one death occurred because of renal failure associated with renal amyloidosis. However, the number of reported concomitant cases of AG and IBD is limited. It may be necessary to accumulate data regarding such concomitant cases to understand these conditions.

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