Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease involving the progressive loss of memory and mental function along with brain atrophy. Approximately 5.8 million Americans age 65 and older are living with this disease, and deaths from Alzheimer’s disease have increased 146%. AD is characterized by the presence of neurofibrillary tangles containing tau and by the abnormal aggregation of Amyloid Plaques (Aβ) with prion-like protein mis-folding. Metabolic changes that occur in AD brains are thought to be indicative of faulty mitochondrial energy production related to the electron transport chain and oxidative.

Keywords: Alzheimer’s disease; Neurodegenerative disease; Amyloid plaques; Mitochondrial dysfunction