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Hindi Review Article
Alterations in Olfaction during Alzheimer Disease, Parkinson Disease and Lewy Body Disease
Patrick Manckoundia1,2,*, Alain Putot1, Rachid Mahmoudi3,4, Mélanie Dipanda1, Sophie Putot1, Sanaa Asgassou1, Anne-Julie Bianchi5 and Hélène Sordet-Guepet1
1Elderly Persons Pole, Hospital of Champmaillot, University Hospital, BP 87 909, 2 rue Jules Violle 21 079 Dijon Cedex, France
2INSERM U1093 Cognition Action Plasticite Sensorimotrice. Universite of Bourgogne Franche Comte BP 27877 F-21078 Dijon Cedex, France
3Department of Internal Medicine and Gerontology, University Hospital, Maison Blanche Hospital, Reims, F-51092, France
4University of Reims Champagne-Ardenne, Faculty of Medicine, E.A 3797, Reims, F-51092, France
5Department of Geriatric Rehabilitation, Hospital of Beaune, BP 40104, Avenue Guigone of Salins, 21203 Beaune Cedex, France
- *Corresponding Author:
- Patrick Manckoundia
Elderly Persons Pole, Hospital of Champmaillot University Hospital
BP87909, 2rueJules Violle 21 079 Dijon Cedex, France
Tel: 0380293970
E-mail: patrick.manckoundia@chu-dijon.fr
Received date October 10, 2016; Accepted date October 18, 2016; Published date October 25, 2016
Citation: Manckoundia P, Putot A, Mahmoudi R, Dipanda M, Putot S, et al. (2016) Alterations in Olfaction during Alzheimer Disease, Parkinson Disease and Lewy Body Disease. J Alzheimers Dis Parkinsonism 6: 274. doi: 10.4172/2161-0460.1000274
Copyright: © 2016 Manckoundia P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Increasing interest is being shown in the link between olfaction, a complex sensory system, and cognition, particularly in the elderly. Olfaction is known to affect cognitive abilities and mood. In this article, we consider the impairment of olfactory function due to Alzheimer disease (AD), Parkinson disease (PD) and Lewy body disease (LBD), through pathological changes in the peripheral and central olfactory structures. The high frequency of these olfactory disorders as well as their early occurrence in AD, PD and LBD suggest that they should be screened for in subjects suffering from these three neurodegenerative diseases.
