Abstract

Organ transplantation has revolutionized modern medicine by providing life-saving treatment for end-stage organ failure. However, the success of organ transplantation is hindered by the immune system’s tendency to reject transplanted organs. The reliance on immunosuppressive drugs to prevent rejection poses long-term risks and complications for transplant recipients. Transplant tolerance, a state where the recipient’s immune system accepts the transplanted organ without the need for immunosuppression, represents a promising approach to enhance longterm graft survival. This article provides an overview of transplant tolerance, its mechanisms, current research efforts, and its potential implications in organ transplantation. By understanding the immunological harmony necessary for successful transplantation, researchers can develop innovative strategies to induce and maintain transplant tolerance, ultimately improving the outcomes and quality of life for organ transplant recipients.