Abstract

The rapid advancement of biologic therapies has revolutionized the treatment of various complex diseases, including cancer and autoimmune disorders. However, optimizing the efficacy and safety of these treatments requires effective therapeutic drug monitoring (TDM) to address the variability in drug response among patients. This review highlights recent advancements in TDM for biologics, focusing on new technologies, methodologies, and clinical applications. Innovations such as enhanced assay sensitivity, improved pharmacokinetic modeling, and personalized dosing strategies are transforming how biologic therapies are monitored and managed. By bridging the gap between preclinical research and clinical practice, these advancements promise to refine treatment protocols, optimize therapeutic responses, and improve patient outcomes. This review aims to provide a comprehensive overview of these developments and their implications for advancing biologic therapy management.