Abstract

Pertussis, commonly known as whooping cough, is a highly contagious respiratory disease caused by the bacterium Bordet Ella pertussis. Despite significant progress in vaccination efforts, pertussis remains a global public health concern, with periodic outbreaks affecting individuals of all age groups. This abstract provides a comprehensive overview of the current state of pertussis vaccines, highlighting recent advances in research, development, and implementation strategies. The historical context of pertussis vaccination is briefly explored, emphasizing the evolution of vaccine formulations from whole-cell vaccines (WP) to acellular vaccines (aP). The transition to acellular vaccines was driven by the need to reduce side effects associated with whole-cell vaccines while maintaining efficacy.