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Advances in Cell Culture: More than a Century after Cultivating Cells
Aline G Souza1*, Izabella C C Ferreira1, Karina Marangoni1,2, Victor A F Bastos1 and Vivian A Goulart11Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of Uberlândia, MG, Brazil
2Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas, SP, Brazil
- Corresponding Author:
- Aline Gomes de Souza
Laboratory of Nanobiotechnology
Institute of Genetics and Biochemistry
Federal University of Uberlândia (UFU)
38400-902, Uberlândia-MG, Brazil
Tel: +55 34 3225-8440
E-mail: alingosouza@yahoo.com.br
Received date: March 23, 2016; Accepted date: April 06, 2016; Published date: April 13, 2016
Citation: Souza AG, Ferreir ICC, Marangoni K, Bastos VAF, Goulart VA (2016) Advances in Cell Culture: More than a Century after Cultivating Cells. J Biotechnol Biomater 6:221. doi:10.4172/2155-952X.1000221
Copyright: © 2016 Souza AG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
To elucidate and understand complex physiological mechanisms, in vivo research is the gold standard. However, in 1907, Harrison started the in vitro cell culture as we know today, opening a path for new assays and techniques. This was a major advance in the scientific field. The possibility to monitor cell growth, differentiation and response to any number of stimuli was a leap for drug trials and screening. More than 100 years has passed, and various cell cultures techniques were developed and perfected. Diverse culture mediums and culture conditions were elaborated to attend the scientist needs. Among those advances, three-dimensional cell culture was a major breakthrough that enables a better representation of the in vivo microenvironmental characteristics. With those continuous advances in cell culture, in vitro assays are getting more reliable providing results that better represent in vivo responses.
