Abstract

Preterm birth remains a significant challenge in maternal-fetal medicine, posing risks to both maternal and neonatal health. Pharmacological interventions have emerged as promising strategies for preterm birth prevention, offering a range of options to prolong gestation and improve neonatal outcomes. This abstract explores recent advancements in pharmacology for preterm birth prevention, including progesterone supplementation, cervical ripening agents, antenatal corticosteroids, and antibiotics for Preterm Premature Rupture of Membranes (PPROM). Recent research efforts have focused on identifying novel pharmacological targets and personalized approaches, driven by advancements in pharmacogenomics. Despite challenges such as optimizing dosing regimens and addressing side effects, pharmacology represents a promising frontier in maternal-fetal medicine, offering hope for reducing the global burden of preterm birth and improving outcomes for mothers and newborns alike.