Abstract

Paediatric immunology and Haematopoietic Stem Cell Transplantation (HSCT) have witnessed significant advancements in recent years, offering new hope to children with various immunodeficiencies and haematological disorders. This review provides a comprehensive overview of the latest research findings and emerging trends in the field. Recent advancements in HSCT techniques, including alternative donor sources such as haploidentical and cord blood transplantation, as well as reduced-intensity conditioning regimens, are examined in detail. Furthermore, we review the latest strategies aimed at improving HSCT outcomes, such as graft engineering, post-transplantation immune reconstitution, and infectious disease management.