Abstract

Advancements in clinical pharmacology methodologies and models have revolutionized drug development and therapeutic optimization. This abstract provides a concise overview of recent progress in optimizing methods and models in clinical pharmacology. Integration of pharmacokinetic and pharmacodynamic modeling enables the prediction of optimal dosing regimens, facilitating personalized medicine approaches. Systems pharmacology offers insights into complex drug interactions and mechanisms of action, guiding the identification of novel drug targets and precision interventions. Pharmacogenomics enhances therapeutic optimization by tailoring drug selection and dosing based on individual genetic profiles. Real-world evidence and digital health technologies provide valuable insights into drug effectiveness and safety in diverse patient populations, informing clinical decision-making and improving patient outcomes. By embracing these advancements, clinical pharmacology is poised to transform drug development and healthcare delivery, ushering in an era of personalized medicine and precision pharmacotherapy.