Abstract

Orthopedic oncology faces unique challenges in delivering chemotherapeutic drugs effectively while minimizing systemic toxicity. Recent advancements in drug delivery systems have propelled the development of innovative carriers designed to enhance targeted delivery to musculoskeletal tumors. This abstract provides a concise overview of these advancements, focusing on key modalities such as nanoparticles, polymeric micelles, liposomes, hydrogels, and magnetic drug delivery. These carriers offer the potential for precise and personalized treatment strategies, allowing for increased drug bioavailability at the tumor site while minimizing adverse effects on healthy tissues. The abstract underscores the transformative impact of these advancements on the future of orthopedic oncology, emphasizing the potential for improved therapeutic outcomes and reduced treatment-related morbidity.