Neonatal and Pediatric Medicine
Open Access

Research Article

Adiponectin and Resistin Levels in Umbilical Serum of Term Neonatesand Relation to Birth Weight

¹Department of Pediatrics, Al-Azhar University, Egypt

²Department of Medical Biochemistry, Al-Azhar University, Egypt & College of Applied Medical Sciences, Taif University, KSA

³Departments of Obstetrics and Gynecology, Al-Azhar University, Egypt

*Corresponding Author:

Ahmad El-Askary
Department of Medical Biochemistry
Al-Azhar University
Egypt & College of Applied Medical Sciences
Taif University, KSA
Tel: 00201010011697
E-mail: ahmadelaskary3@gmail.com

Received Date: April 29, 2017; Accepted Date: May 29, 2017; Published Date: June 2, 2017

Citation: Mohamed S, El-Askary A, Megahed A (2017) Adiponectin and Resistin Levels in Umbilical Serum of Term Neonates and Relation to Birth Weight. Neonat Pediatr Med 3: 127. doi:10.4172/2572-4983.1000127

Copyright: © 2017 Mohamed S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Background: Optimal birth weight is an important factor for the future health of the newborns. Aberrations in fetal growth are associated with adverse health effects both in early life and in late childhood and adulthood. Fetal growth is controlled by both maternal hormones and nutrition. Adipokines, including resistin and adiponectin are known regulators of energy metabolism; although their role in the regulation of fetal growth still poorly understood. Objective: The aim of the present study was to evaluate the relationship between adiponectin and resistin with abnormalities of neonatal birth weight and to identify the correlation between these proteins and various maternal and neonatal factors. Patients and Methods: Comparative controlled study included 120 full term newborns recruited from Al-Azhar University Hospital (New Damietta), during the period from January 2016 to February 2017. Included newborns were divided into 3 groups; group 1) 40 small for gestational age (SGA) newborns, 2) 40 large for gestational age (LGA) newborns, and group 3) 40 apparently healthy appropriate for gestational age (AGA) newborns, were selected randomly. Serum umbilical cord adiponectin and resistin were measured by ELISA. Results: There was no significant difference between groups as regard to maternal age (P: 0.797), parity (P: 0.77), gestational age (P: 0.528) and BMI (P: 0.091). Umbilical cord resistin and adiponectin were significantly lower among LGA group (resistin: 16.9 ± 1.92 ng/ml; adiponectin: 6.74 ± 2.23 ᶙg/ml), and significantly elevated among SGA group (resistin: 23.03 ± 3.97 ng/ml; adiponectin: 14.92 ± 3.19 ᶙg/ml) than AGA group (resistin: 17.98 ± 1.89 ng/ml; adiponectin: 11.04 ± 1.91 ᶙg/ml; P

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