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Hindi Acute Malaria: 8 Years (2008-2015) Experience of Distribution, Clinical Manifestations, Severity and Outcomes from North India
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Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
This north Indian retrospective hospital-based observational study analysed the distribution, clinical features, the outcomes and
the burden of complications of acute malaria associated with mono and co-infections by P. vivax and P. falciparum of the 1663 patients
presenting between 2008-2015, 59.4% and 36.9% had P. vivax and P. falciparum mono-infections while 3.6% were co-infected. P.
falciparum cases peaked between 2010-2012, there after; P. vivax has emerged as the dominant species. Severe thrombocytopenia
(29.8%), shock (22.7%), renal dysfunction (19.8%), liver dysfunction (17.5%), hypoglycaemia (10.5%), cerebral malaria (8.3%), severe
anaemia (5%) and respiratory distress (4.5%) were the main complications and 1% patients succumbed to malaria. While P. vivax monoinfection
was significantly associated with renal dysfunction and severe thrombocytopenia, co-infection with P. falciparum was significantly
associated with hypoglycaemia, neurological dysfunction, acute respiratory distress and unfavourable outcome. Renal dysfunction was
significantly associated with concomitant liver and respiratory dysfunction (p<0.05) and mortality.
