Abstract

The incidence of multidrug-resistant-Gram negative bacilli (MDR-GNB) infections is increasing. Ceftazidime-avibactam (CAZ-AVI) is recommended as one of the preferred agents for the treatment of infections caused by carbapenem-resistant Enterobacterales (CRE) or Pseudomonas aeruginosa with Difficult-To-Treat Resistance (DTR-PA). Given the rising threat of infections caused by MDR-GNB, in particular Carbapenem-Resistant (CR) pathogens, it is important to understand the use of CAZ-AVI for the treatment of GNB infections with limited treatment options. Evidence from 28 real-world studies suggest that CAZ-AVI is an effective and well-tolerated alternative to standard of care antibiotics for treating different types of infection caused by MDR-GNB, including CRE and MDR-Pseudomonas spp. Notably, CAZ-AVI is well tolerated even in severely or critically ill patients, patients with multiple comorbidities, or those with bacteremia. These real-life experiences provide valuable insights into the use of CAZ-AVI across diverse types of GNB infections for which limited treatment options exist.

Keywords: Ceftazidime-avibactam ; Multidrug-resistant gramnegative bacilli infections; Carbapenem-resistant Enterobacterales;Pseudomonas aeruginosa; Real-world