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A Rare Case of Prostatic Extra Gonadal Germ Cell Tumor in a Young Adult: Review of the Literature
Spyidon Sydris1*, Philippe Aftimos1, Aspasia Georgala2, Nicolas Sirtaine3, Ahmad Awada1 and Thierry Gil1
1Department of Medical Oncology, Jules Bordet Institute, Belgium
2Department of Infectious Diseases, Jules Bordet Institute, Belgium
3Department of Anatomy Pathology, Jules Bordet Institute, Belgium
- Corresponding Author:
- Spyidon sideris
Department of Medical Oncology
Jules Bordet Institute, Rue Heger Bordet 1
1000, Brussels, Belgium
Tel: +32 476 641932
E-mail: sideris.spyridon@hotmail.com
Received date: February 04, 2014; Accepted date: March 24, 2014; Published date: April 03, 2014
Citation: Sydris S, Aftimos P, Georgala A, Sirtaine N, Awada A, et al. (2014) A Rare Case of Prostatic Extra Gonadal Germ Cell Tumor in a Young Adult: Review of the Literature. J Clin Diagn Res 2:112. doi:10.4172/2376-0311.1000112
Copyright: © 2014 Sydris S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
We report the case of a 29 year-old male who presented with hemospermia. A biopsy revealed an embryonal rhabdomyosarcoma of the prostate and the patient was treated with pre-operative chemotherapy according to the pediatric protocol IVAD (Ifosfamide - Actinomycin - Doxorubicin – Vincristine) followed by prostatectomy. Pathologic examination of the prostate showed the persistence of an immature teratoma without residual rhabdomyosarcoma. The choice of consolidation chemotherapy with a platinum-based regimen was based on the diagnosis of an extra-gonadal non-seminomatous germ cell tumor with an excellent clinical outcome. Extragonadal germ cell tumors of the prostate in adults are very rare and aggressive. The presence of a sarcomatous component represents a poor prognostic factor and it may pose diagnostic pitfalls just like in the case we report. Early diagnosis and multimodality treatment are necessary to improve overall survival.
