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Hindi Research Article
A Pilot Study - Comparison between a Novel Combination of Bioactive Glass with Clodronate and Bioactive Glass Alone as a Treatment for Chronic Periodontitis
Kirsi Rosenqvist1*, Mervi Gürsoy2,3#, Eija Könönen2,3, Ulvi K Gürsoy2 and Anne M Juppo11Division of Pharmaceutical Chemistry and Technology, Formulation and Industrial Pharmacy Unit, Faculty of Pharmacy, University of Helsinki, Viikinkaari, Finland
2Department of Periodontology, Institute of Dentistry, Lemminkäisenkatu 2, University of Turku, Finland
3Oral Health Care, Welfare Division, City of Turku, FI20101 Turku, Finland
4Author contributed equally to this work
- Corresponding Author:
- Rosenqvist K
Division of Pharmaceutical Chemistry and Technology
Formulation and Industrial Pharmacy Unit
Faculty of Pharmacy, University of Helsinki
Viikinkaari 5 (P.O. Box 56), 00014, Finland
Tel: +358405124993
Fax: +358919159144
E-mail: kirsi.rosenqvist@helsinki.fi
Received date: June 29, 2017; Accepted date: July 19, 2017; Published date: July 26, 2017
Citation: Rosenqvist K, Gürsoy M, Könönen E, Gürsoy UK, Juppo AM (2017) A Pilot Study - Comparison between a Novel Combination of Bioactive Glass with Clodronate and Bioactive Glass Alone as a Treatment for Chronic Periodontitis. J Biotechnol Biomater 7:265. doi:10.4172/2155-952X.1000265
Copyright: © 2017 Rosenqvist K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Abstract
Bioactive glass (BAG) and clodronate are both used for bone regeneration. In this pilot clinical study, we compared the effect of BAG and a novel BAG+clodronate combination as a topical maintenance phase treatment for chronic periodontitis. Two dental residual pockets were treated in each subject (n=10): one with BAG alone and the other with combination product, by applying the products subgingivally for 10 min once a week for four weeks. We describe the effects of these investigational products to the clinical parameters of periodontitis and two bone metabolism markers (osteoprotegerin and osteocalcin). Additionally, subjective satisfaction for the treatment was evaluated. The results must be considered as directional, understanding that further investigation is needed to confirm the findings. Based on clinical parameters measured both treatments could benefit as maintenance therapy for chronic periodontitis. The positive effect of the combination product on tooth sensitivity may bring additional benefits in comparison to the use of BAG alone. Both treatments were well tolerated and safe.
