A New Role for ApoE-Not Only in Alzheimer's Disease?
Received Date: Mar 26, 2018 / Accepted Date: Jun 15, 2018 / Published Date: Jun 22, 2018
Abstract
The by far most relevant genetic risk factor for Alzheimer’s disease is possession of the allelic epsilon 4 variant of the cholesterol transporter apolipoprotein E. The apolipoprotein E allelic polymorphism impacts on both histopathological hallmarks of Alzheimer’s disease, the intraneuronal tau-aggregates forming neuropil threads and neurofibrillary tangles and the extracellular plaques built-up by beta-amyloid. Autophagy is a crucial process in neurons and plays a central role in cellular degradation of protein aggregates including those composed of tau or beta-amyloid. We discuss available evidence for a role of the apolipoprotein E polymorphism in autophagy.
Keywords: Alzheimer’s disease; Autophagy; Apolipoprotein E polymorphism
Citation: Ohm TG, Meske V (2018) A New Role for ApoE-Not Only in Alzheimer’s Disease? J Alzheimers Dis Parkinsonism 8: 442. Doi: 10.4172/2161-0460.1000442
Copyright: © 2018 Ohm TG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Recommended Journals
Open Access Journals
Article Tools
Article Usage
- Total views: 3706
- [From(publication date): 0-2018 - Nov 21, 2024]
- Breakdown by view type
- HTML page views: 3052
- PDF downloads: 654