A New Role for ApoE-Not Only in Alzheimer's Disease?
Received Date: Mar 26, 2018 / Accepted Date: Jun 15, 2018 / Published Date: Jun 22, 2018
Abstract
The by far most relevant genetic risk factor for Alzheimer’s disease is possession of the allelic epsilon 4 variant of the cholesterol transporter apolipoprotein E. The apolipoprotein E allelic polymorphism impacts on both histopathological hallmarks of Alzheimer’s disease, the intraneuronal tau-aggregates forming neuropil threads and neurofibrillary tangles and the extracellular plaques built-up by beta-amyloid. Autophagy is a crucial process in neurons and plays a central role in cellular degradation of protein aggregates including those composed of tau or beta-amyloid. We discuss available evidence for a role of the apolipoprotein E polymorphism in autophagy.
Keywords: Alzheimer’s disease; Autophagy; Apolipoprotein E polymorphism
Citation: Ohm TG, Meske V (2018) A New Role for ApoE-Not Only in Alzheimer’s Disease? J Alzheimers Dis Parkinsonism 8: 442. Doi: 10.4172/2161-0460.1000442
Copyright: © 2018 Ohm TG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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