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Hindi A New Cluster-Based MOF for Selective Gas Sorption and Treatment Effect on Acute Glomerulonephritis by Reducing NF-NF-κβ Pathway Activation and Cytokines Release
*Corresponding Author: Gang Ma, Infectious Disease, The Affiliated Hospital of Northwest University, P.R. China, Tel: +86 718 843 9097, Email: gang_ma11@sina.comReceived Date: Aug 27, 2019 / Accepted Date: Sep 20, 2019 / Published Date: Sep 27, 2019
Citation: He XW, Sun L, Zhang JJ, Xu YX, Ma G, et al. (2019) A New Cluster-Based MOF for Selective Gas Sorption and Treatment Effect on Acute Glomerulonephritis by Reducing NF-κβ Pathway Activation and Cytokines Release. Cell Mol Biol 65: 155.
Copyright: © 2019 He XW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
A novel Co(II)-containing metal-organic framework [Co3(OH)2(H2TCPP)2](DMF)3 (1) based on a linear trinuclear Co(II) cluster-based unit has been successfully prepared by using a nanosized tetracarboxylate ligand 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (H4TCPP) as the organic building block under the solvothermal reaction. Gas adsorption studies reveal that the mixtures of C2H2/CH4 and C2H2/CO2 could be selectively separated by the obtained resulting solvent free 1 (denoted as 1a hereafter). To deep evaluate the protective function of complex for AGN disease in vitro, the following experiments were conducted. Firstly, real time RT-PCR was carried out to determine the relative expression of Nf-κβ and tNf-α in the glomerulus cells after bacterial infection along with complex 1 treatment. Then, the ELISA was conducted to determine the IL-1β and IL-6 released by glomerular cells after complex 1 treatment. Finally, the results obtained through molecular docking exhibited possible regulation mechanism on the binding affinity between compound 1 and target protein.
