Journal of Alzheimers Disease & Parkinsonism
Open Access

A Blood Screening Test for Dementia with Lewy Bodies for Primary Care

Melissa Petersen^1,2, Tanis J Ferman³, Fan Zhang^1,2, Otto Pedraza³, Zbigniew K Wszolek⁴, Owen A Ross¹, Tori Como¹, David Julovich¹, Leigh A Johnson¹, James Hall^1,2, Neill R Graff-Radford⁴ and Sid O’Bryant^1,2*

¹Department of Psychology, Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA

²Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA

³Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida, USA

⁴Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA

Received Date: Nov 03, 2023 / Published Date: Dec 04, 2023

Citation: Petersen M, Ferman TJ, Zhang F, Pedraza O, Wszolek ZK, et al. (2023) A Blood Screening Test for Dementia with Lewy Bodies for Primary Care. J Alzheimers Dis Parkinsonism. 13:584.DOI: 10.4172/2161-0460.1000584

Copyright: © 2023 Petersen M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Introduction: We sought to cross-validate our previously published blood test for detecting Dementia with Lewy Bodies (DLB).

Method: Plasma samples were analyzed on 428 individuals (DLB n=89, Parkinson’s Disease (PD) without dementia n=126, Alzheimer’s Disease (AD) n=108, Normal Controls (NC) n=105).

Results: The proteomic profile discriminated DLB and PD from NC with an AUC (Area Under the Curve) of 0.96 with demographics of age, sex and education. The proteomic profile also distinguished DLB from the PD group with an AUC of 0.92 with demographics. It further distinguished DLB, PD and AD from NC with an AUC of 0.95 as well as DLB from AD with an AUC of 0.92 with demographics.

Discussion: This data provides additional evidence of the potential utility of a multi-tiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from NC, PD and AD that can be implemented in primary care settings to aid in the referral process.

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