ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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  • Research Article   
  • Clin Pharmacol Biopharm; 2021, Vol 10(3): 213

18-Glycyrrhetinic Acid Chalcones and Its Salts with Their Mass Fragmentation Pattern

Shazia Kousar1,2*, Sobia Shahzadi2, Fehmeeda Bibi1, Madiha Irfan1 and Muhammad Ahmad Mudassir1
1Department of Chemistry, KhwajaFareed University of Engineering and Information Technology, Pakistan
2Department of Chemistry, Government College UniversityFaisalabad, Pakistan
*Corresponding Author : Shazia Kousar, Department of Chemistry, Khwaja Fareed University of Engineering and Information Technology, Pakistan, Tel: +923027086227, Email: Shazia_hej@hotmail.com

Received Date: Feb 06, 2021 / Accepted Date: Mar 20, 2021 / Published Date: Mar 27, 2021

Abstract

This work reveals the synthesis of chalcones which are derived from 18β-glycyrrhetinic acid, through its keto derivative. First of all by means of Jones oxidation the hydroxyl group of glycyrrhetinic acid at position 3 oxidized to keto group. Then α, β-unsaturated ketones (enones) are produced when this keto group is treated with different benzaldehyde through Claisen Schmidt reaction. We also prepared potassium and sodium salts of all these compounds. By mean of thin layer chromatography reactions are monitored and by means of chromatographic techniques reaction products are purified. By using spectroscopic techniques like MS, 1HNMR and IR 18β-glycyrrhetinic acid derivatives are characterized. By the presence of all the possible peaks 1HNMR spectra confirms the products formation. The Claisen Schmidt synthesis has been done successfully this is shown by the existence of aromatic proton. Their fragmentation pattern and mass spectra of all the compounds discussed in detail with schemes. Almost same fragmentation pattern is shown by all the compounds. Fragments had shown by all the compounds at m/z 262, 55, 135 and 303 along with other fragments. Formation of potassium and sodium salts of compound 3, its keto derivative and of chalcones confirmed by the IR of salts.

Citation: Kousar S, Shahzadi S, Bibi F, Irfan M, Mudassir MA (2021) 18β-Glycyrrhetinic Acid Chalcones and Its Salts with Their Mass Fragmentation Pattern. Clin Pharmacol Biopharm 10: 213.

Copyright: © 2021 Kousar S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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