Abstract

Phosphatidylcholine is a polyunsaturated fatty acid compound and is an essential cell membrane phospholipid. It is important in maintaining normal membrane structure and increase cell protection against external factors. Maintenance of the integrity of the cell membrane is vital as destructive cell membrane results in the release of lowdensity lipoprotein cholesterol into the blood. Phosphatidylcholine is also effective in lowering cholesterol level by enhancing cholesterol efflux, down-regulating fatty acid synthesis and increasing the cholesterol oxidation to bile salts. It is well known to decreases the triglycerides level in blood and dissolves atherosclerotic plaques. Atherosclerosis has long been established as a major risk factor of cardiovascular disease, which develops when scar tissues form on the damage arteries wall and cause the buildup of plaques. Both hypercholesterolemia and hypertriglyceridemia contribute towards atherosclerosis as excessive cholesterol and triglycerides in blood accumulate along the wall of blood vessels and eventually cause blockage. Considering the beneficial effects of phosphatidylcholine, this work hypothesised that PlaqX Forte administration in a group of 13 volunteers may improve their blood glucose and lipid profile. A total of 25 ml of PlaqX Forte infusions diluted in 250 ml of 5% glucose were administered intravenously between three to four times per week. Blood samples were collected for the analysis of blood glucose and lipid profile before treatment and after 7 to 12 times of infusions. The results showed a significant reduction in total cholesterol, triglycerides, low-density lipoprotein cholesterol and haemoglobin A1c levels, suggesting that PlaqX Forte infusion may be used as a remedy for hypercholesterolemia and hypertriglyceridemia. However, a reduction in high-density lipoprotein cholesterol level was observed in this study. Further investigation is required following the recommended full course of 30 infusions to fully understand the efficacy of PlaqX Forte therapy in the management of cardiovascular, blood vessels and cellular health.

Keywords: Phosphatidylcholine; Atherosclerosis; Cardiovascular disease; Cholesterol; Triglycerides