Tea Polyphenol Extracts as a Natural Dietary Supplement to Current Treatments of HIV/AIDS

Taylor-Robinson AW^*

Infectious Diseases Research Group, School of Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD 4702, Australia

*Corresponding Author:

Taylor-Robinson AW
Infectious Diseases Research Group
School of Medical and Applied Sciences
Central Queensland University, Rockhampton
QLD 4702, Australia
Tel: +61 7 4923 2008
E-mail: a.taylor-robinson@cqu.edu.au

 

Received Date: May 17, 2016; Accepted Date: July 14, 2016; Published Date: July 18, 2016

Citation: Taylor-Robinson AW (2016) Tea Polyphenol Extracts as a Natural Dietary Supplement to Current Treatments of HIV/AIDS. J Tradi Med Clin Natur 5:188. doi:10.4172/2167-1206.1000188

Copyright: © 2016 Taylor-Robinson AW. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

HIV; AIDS; Tea; Polyphenol; Catechin; Theaflavin

Introduction

The human immunodeficiency virus (HIV) belongs to the Lentivirus genus, a member of the Retroviridae family of enveloped, single-stranded, positive-sense RNA viruses that replicate characteristically in a host cell through the process of reverse transcription. HIV is the etiological agent of acquired immunodeficiency syndrome (AIDS) which affects the human immune system including CD4+ T lymphocytes, monocytes, macrophages and dendritic cells [1]. Worldwide, more than 35 million people are thought to live with HIV [2], of whom 69% reside in sub- Saharan Africa where one adult in every 20 is HIV-positive [3]. The Centres for Disease Control and Prevention estimate that in the USA approximately 50,000 people contract HIV each year [4]. The latest statistics from China reveal that 501,000 people had HIV/AIDS among whom 205,000 were living with AIDS [5]. Drug injection using contaminated shared needles [6], unprotected sexual contact, percutaneous blood exposure, mucus membrane exposure to contaminated blood or other body fluids, mother-to-child transmission and receipt of contaminated blood products are all identified as major routes of HIV transmission [7].

There are over 25 anti-retroviral (ARV) drugs licensed for HIV therapy [8]. A range of side effects including liver, metabolic and blood disorders, constipation, fever, muscular dystrophy, lipoatrophy, hypersensitivity reactions, peripheral neuropathy, hyperlactemia, pancreatitis and mitochondrial toxicity [1,9,10], as well as multi-drug resistance and toxicity caused by the high genetic variability of HIV, have restricted long term treatment with those currently available ARV drugs [11]. The wealth of botanical-based therapies that are both efficacious and safe has prompted research to screen different known medicinal plants for anti-HIV activity, of which different types of tea – with their broad range of polyphenols as an active ingredient – could be considered as among the most important [12].

Polyphenols have been recognized as extremely important plantderived dietary compounds due to producing a vast range of effects considered to be beneficial to humans. Of several polyphenol sources in the human diet, tea is one of the most consumed beverages. This is prepared from leaves of the evergreen shrub Camellia sinensis . Globally, over 4.52 million tons of tea was produced in 2014 [13]. Depending on the degree of processing and fermentation, tea is divided into green tea, which is consumed mostly in South East Asian countries, black tea, which is commonly consumed in the Indian subcontinent and Western societies, and Pu-erh, white, yellow and oolong teas that are produced and drunk mainly in China [14].

Green, Pu-erh and black teas contain such phenolic compounds as (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC), (-)- epigallocatechin gallate (EGCG), (-)-gallocatechin gallate (GCG), theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3 ׳-gallate (TF2B) and theaflavin-3,3 ׳-digallate (TF3), which have demonstrated anti-HIV activity in several in vitro and in vivo studies [12,15]. While all are classified as flavonoids, green tea polyphenols consist mostly of EGCG and other catechin gallates, whereas theaflavins are the main constituents of black tea and more fermented varieties of Pu-erh.

Tea polyphenols are involved in subcellular pathways such as JAK/ STAT signaling [16], in addition to intercellular and virus-cell interactions [15].These exert anti-viral and immunomodulatory effects on HIV infection via different mechanisms including inhibition of virus replication, of HIV-induced cytopathic activities, and of antigen and reverse transcriptase (RT) expression, prevention of virus attachment and destruction of virus particles. In particular, EGCG inhibits HIV-1 replication in several steps of the virus life cycle by interfering with RT and protease activity, blocking gp120-CD4 interaction via binding to CD4 and destroying virus particles [17-21]. Tea polyphenols also show activities against HIV infection in concentrations that are non-toxic for mammalian cell lines in vitro [22]. Pu-erh tea has been studied mostly in the form of crude extracts and isolated compounds were not assessed; however, these preparations were successful in demonstrating anti-HIV properties [15].

A number of beneficial properties have been attributed to tea polyphenols, including anti-viral functions [15,23]. When drank regularly, tea has health-enhancing effects due to its highly active antioxidant and anti-inflammatory polyphenolic compounds, especially catechins [24].The European Food Safety Authority reported that each 100 ml of green tea contains about 126 mg of catechin derivatives [25]. As a principal property of polyphenols, anti-oxidant effects are likely to play a key role in their noted anti-retroviral activities. Also, immunomodulation could be one of the mechanisms involved in the anti-HIV function of these molecules [14].

It is proposed that in future tea polyphenols and polyphenol-rich extracts could be utilized as dietary supplements in combination with conventional anti-HIV medicaments. As investigation in humans of the protective effects of tea-derived polyphenolic compounds is very limited to date, there is a pressing requirement to perform detailed clinical trials in order to acquire sufficient and robust data to either substantiate or refute the putative beneficial role of tea polyphenols in the therapy of HIV/AIDS patients.

Conflict of Interests

The author does not have any conflict of interest to declare.

References

1. Ramana LN, Anand AR, Sethuraman S, Krishnan UM (2014) Targeting strategies for delivery of anti-HIV drugs. J Control Release 192: 271-283.
2. Sabapathy K (2013) Global roll-out of HIV treatment. Medicine 41: 479-482.
3. UNAIDS (2015) AIDS by the numbers 2015 unaids.org, Geneva.
4. Centers for Disease Control and Prevention (2012) Estimated HIV incidence in the United States, 2007-2010. HIV Surveillance Supplemental Report 17:4
5. Crawford ND, Vlahov D (2010) Progress in HIV reduction and prevention among injection and non-injection drug users. J Acquir Immune Defic Syndr 55 (Suppl 2): S84-S87.
6. Donovan S (2013) Pediatric HIV: current recommendations for diagnosis and treatment. Clin Microbiol Newsl 35: 127-131.
7. De Clercq E (2009) The history of antiretrovirals: key discoveries over the past 25 years. Rev Med Virol 19: 287-299.
8. Narayan LC, Rai VR, Tewtrakul S (2013) Emerging need to use phytopharmaceuticals in the treatment of HIV. J Pharm Res 6: 218-223.
9. Panel on Antiretroviral Guidelines for Adults and Adolescents (2016) Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. US Department of Health and Human Services.
10. Wainberg MA, Friedland G (1998) Public health implications of antiretroviral therapy and HIV drug resistance. JAMA 279: 1977-1983.
11. Kanwar J, Taskeen M, Mohammad I, Huo C, Chan TH, et al. (2012) Recent advances on tea polyphenols. Front Biosci 4: 111-131.
12. Food and Agriculture Organization (2015) Food and Agriculture Organization  of the United Nations Statistics Division
13. Khan N, Mukhtar H (2007) Tea polyphenols for health promotion. Life Sci 81: 519-533.
14. Liu S, Lu H, Zhao Q, He Y, Niu J, et al. (2005) Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41. Biochim Biophys Acta 1723: 270-281
15. Giunta B, Obregon D, Hou H, Zeng J, Sun N, et al. (2006) EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-γ: role of JAK/STAT1 signaling and implications for HIV-associated dementia. Brain Res 1123: 216-225.
16. Kawai K, Tsuno NH, Kitayama J, Okaji Y, Yazawa K, et al. (2003) Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding. J Allergy Clin Immunol 112: 951-957.
17. Fassina G, Buffa A, Benelli R, Varnier OE, Noonan DM, et al. (2002) Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent. AIDS 16: 939-941.
18. Yamaguchi K, Honda M, Ikigai H, Hara Y, Shimamura T (2002) Inhibitory effects of (-)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1). Antiviral Res 53: 19-34.
19. Haneda E, Furuya T, Asai S, Morikawa Y, Ohtsuki K (2000) Biochemical characterization of casein kinase II as a protein kinase responsible for stimulation of HIV-1 protease in vitro. Biochem Biophys Res Commun 275: 434-439.
20. Tao P, Zhongguo Yi, Xue Ke, Xue Yuan, Xue Bao (1992) The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerases 14: 334-338.
21. Williamson MP, McCormick TG, Nance CL, Shearer WT (2006) Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: potential for HIV-1 therapy. J Allergy Clin Immunol 118: 1369-1374.
22. Huang SH, Tang YZ, Zhou XM, Xie G, Kurihara H, et al. (2010) Study on anti-influenza virus effect of tea polyphenols in vitro and in vivo. Chaye Kexue 30: 302-308.
23. Wierzejska R (2014) Tea and health – a review of the current state of knowledge. Przegl Epidemiol 68: 501-6, 595-599.
24. EFSA Panel on Dietetic Products, Nutrition and Allergies (2010) Scientific Opinion on the substantiation of health claims related to Camellia sinensis (L.) Kuntze (tea), including catechins in green tea and tannins in black tea, and protection of DNA, proteins and lipids from oxidative damage (ID 1103, 1276, 1311, 1708, 2664), reduction of acid production in dental plaque (ID 1105, 1111), maintenance of bone (ID 1109), decreasing potentially pathogenic intestinal microorganisms (ID 1116), maintenance of vision (ID 1280), maintenance of normal blood pressure (ID 1546) and maintenance of normal blood cholesterol concentrations (ID 1113, 1114) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 8: 1463.