Insights in Gynecologic Oncology
Open Access

Ovarian cysts; Functional cysts; Pathological cysts; Polycystic Ovary Syndrome (PCOS); Reproductive health; Hormonal imbalance

Introduction

Ovarian cysts are broadly categorized into functional and pathological cysts. Functional cysts include follicular cysts and corpus luteum cysts, which often resolve on their own without treatment. Pathological cysts, such as dermoid cysts, cystadenomas, and endometriomas, can develop due to abnormal cell growth and may require surgical intervention. Polycystic Ovary Syndrome (PCOS) is another significant condition marked by the development of multiple small cysts and hormonal imbalances, leading to irregular menstruation and potential fertility issues [1]. The diagnosis of ovarian cysts is typically done through pelvic examinations, ultrasounds, or other imaging techniques. Management depends on the size, type, and symptoms associated with the cyst. While many cysts are asymptomatic, some may cause abdominal pain, bloating, or irregular menstrual cycles. Large or ruptured cysts can lead to complications like ovarian torsion or hemorrhage, necessitating prompt medical care.

Treatment options range from watchful waiting to surgical procedures, such as cystectomy or oophorectomy, depending on the severity [2-5]. Hormonal therapies may also be used to prevent the recurrence of cysts. Understanding the nature and behavior of ovarian cysts is crucial for effective management and maintaining reproductive health. Further research is required to explore the etiology, prevention, and improved treatment modalities for ovarian cysts. Ovaries are a vital component of the female reproductive system, primarily responsible for producing eggs and secreting hormones like estrogen and progesterone, which regulate menstrual cycles and fertility. Ovarian health is crucial for overall reproductive function, and various conditions can affect it, one of the most common being the formation of ovarian cysts.

Ovarian cysts are fluid-filled sacs that form in or on the surface of the ovaries. They are relatively common, particularly during a woman’s reproductive years, and most are benign and asymptomatic. These cysts often develop as part of the normal menstrual cycle, such as follicular cysts that form when an egg doesn’t release properly during ovulation. However, other types of cysts, such as dermoid cysts, endometriomas, or cystadenomas, can develop due to more complex underlying conditions, sometimes requiring medical intervention. While many cysts are harmless and resolve on their own, some may cause symptoms like pelvic pain, bloating, or irregular periods. In rare cases, cysts can grow large, rupture, or lead to complications like ovarian torsion, which can cause severe pain and may require emergency treatment. Polycystic Ovary Syndrome (PCOS), a condition marked by multiple small cysts in the ovaries, is another significant ovarian disorder. It involves hormonal imbalances, which can lead to irregular periods, infertility, and metabolic issues.

Discussion

The prevalence and potential complications associated with ovarian cysts necessitate a clear understanding of their types, causes, symptoms, and treatment options. While functional cysts often resolve without intervention, pathological cysts may require more extensive medical or surgical treatment. In this context, early detection and management of ovarian cysts are critical for preventing complications and preserving reproductive health. This introduction will provide a foundation for understanding the significance of ovarian cysts, their diagnosis, and their management. Ovarian cysts are a frequent gynecological issue, typically encountered during a woman’s reproductive years. Although many ovarian cysts are benign and self-limiting, the complexity of their origins, types, and potential consequences necessitates a thorough discussion of their clinical implications. The most common cysts are functional ovarian cysts, which are part of the normal menstrual cycle [5-8]. These include follicular cysts, formed when a follicle does not release an egg, and corpus luteum cysts, which form after an egg is released and the follicle does not dissolve properly. These functional cysts usually resolve on their own within a few months and rarely cause significant symptoms. However, they can occasionally grow large enough to cause pain or pressure in the pelvis.

Conclusion

In contrast, pathological ovarian cysts develop due to abnormal cell growth and are not related to the ovulation process. Examples include dermoid cysts, which can contain various tissue types such as hair, fat, and bone, and cystadenomas, which form on the ovarian surface and are filled with a watery or mucous fluid. Another type, endometriomas, is associated with endometriosis and occurs when endometrial tissue grows in the ovaries. These cysts can cause more severe symptoms, including chronic pelvic pain and infertility, and may require surgical intervention, especially if they grow large or are suspected to be malignant.

A significant ovarian condition linked to cyst formation is Polycystic Ovary Syndrome (PCOS). In PCOS, the ovaries develop numerous small cysts, which are often accompanied by hormonal imbalances, irregular menstrual cycles, and anovulation (lack of ovulation). PCOS is not only a reproductive disorder but also a metabolic one, often associated with insulin resistance, obesity, and an increased risk of type 2 diabetes and cardiovascular disease. Managing PCOS often involves a multidisciplinary approach, including lifestyle changes, hormonal treatments, and medications to regulate blood sugar levels and manage symptoms.

References

1. Haviland JS, Owen JR, Dewar JA, Agrawal RK, Barrett J, et al. (2013)The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol 14: 1086-1094.

Indexed at, Google Scholar, Crossref

2. Whelan T, MacKenzie R, Julian J, Levine M, Shelley W, et al. (2002)Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst 94: 1143-1150.

Indexed at, Google Scholar, Crossref

3. Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, et al. (2010)Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 362: 513-520.

Indexed at, Google Scholar, Crossref

4. Wang SL, Fang H, Song YW, Wang WH, Hu C, et al. (2019)Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non-inferiority, open-label, phase 3 trial. Lancet Oncol 20: 352-360.

Indexed at, Google Scholar, Crossref

5. Sedlmayer F, Reitsamer R, Wenz F, Sperk E, Fussl C, et al. (2017)Intraoperative radiotherapy (IORT) as boost in breast cancer. Radiat Oncol 12: 1-7.

Indexed at, Google Scholar, Crossref

6. Fastner G, Reitsamer R, Urbański B, Kopp P, Murawa D, et al. (2020)Toxicity and cosmetic outcome after hypofractionated whole breast irradiation and boost-IOERT in early stage breast cancer (HIOB): first results of a prospective multicenter trial (NCT01343459). Radiother Oncol 146: 136-142.

Indexed at, Google Scholar, Crossref

7. Burgos-Burgos J, Vega V, Macias-Verde D, Gómez V, Travieso-Aja M, et al. (2021)Hypofractionated whole breast irradiation after IORT treatment: evaluation of acute toxicity and cosmesis. Clin Transl Oncol 23: 179-182.

Indexed at, Google Scholar, Crossref

8. McCart Reed AE, Kutasovic JR, Lakhani SR, Simpson PT (2015)Invasive lobular carcinoma of the breast: Morphology, biomarkers and ’omics.Breast Cancer Res 17: 12.

Indexed at, Google Scholar, Crossref