Journal of Neuroinfectious Diseases
Open Access

A 60-year-old Caucasian male with past medical history of hypertension, hyper-lipidemia and amphetamine abuse presented with chief complaint of painful left eye blindness and worsening vision of the right eye. Five months prior he noticed a painless ulcer on the dorsum of his penis. The ulcer did not improve and was intermittently painful. Two months after the appearance of the ulcer he started developing a pruritic, macular rash in his upper and lower extremities (Figures 1-2). One month after developing the rash, he started having intermittent transient episodes of vision loss in the left eye. These episodes lasted for 45-60 seconds; were associated with eye pain and photophobia which was partially alleviated by aspirin and acetaminophen. During this time, he also reported having a 40 pound unintentional weight loss and the appearance of multiple lesions on his penis and scrotum (Figure 3). The left eye vision loss progressed to complete permanent loss of vision. One week after the complete vision loss in his left eye he began to have transient vision loss in his right at which point he saw an ophthalmologist. He was seen by ophthalmology and was diagnosed with pan uveitis on the left eye and edema on the right optic nerve. RPR was reactive with a dilution of 1:256 at which point he was admitted to our hospital for further work up. Social history was pertinent for multiple sexual partners in his life, with 3 in the past 2 years without the use of contraception. He participated in oral and anal sex, with only female partners and denied any previous history of sexually transmitted disease. On admission vital signs were within normal limits and he was AAOx3. Extra ocular movements were intact with bilateral pupil constriction and swelling noted of left globe which was erythematous, with ecchymosis. He was unable to perceive images, movement or light with the left eye. A non-painful, diffuse maculopapular rash was noted in all extremities and the upper trunk. 5 genital ulcers measuring 1 cm X 1cm on the dorsum of the penis and scrotum were noted. Proprioception was decreased bilaterally. Laboratory studies showed a normal CBC and BMP. The Hepatitis panel and HIV were negative. A urine drug screen was positive for amphetamines. A lumbar puncture was performed with an opening pressure of 10cm H2 0, CSF fluid was hazy and pink CSF. Protein was 63.2 mg/dl, glucose 57 mg/dl, WBC 213/ mm3 , Mononuclear 91%, RBC 5,000/mm3 . Serum VDRL was reactive with a dilution of >1:512. CSF VDRL was non-reactive. Serum TPPA was reactive. Herpes panel, Tuberculosis, Enterovirus in the CSF were all negative. Neisseria and Gonorrhoea were negative. Because of the patient’s persistent headache and painful vision loss he underwent a bilateral temporal artery biopsy which showed no inflammatory infiltrates, giant cells, or granulomas. No steroids were given. CT and MRI of the brain did not show any abnormalities. Given his positive lumbar puncture, and clinical exam findings he was diagnosed with secondary syphilis and neurosyphilis with ocular involvement. He was started on Penicillin G-4 million units every 4 hours, for a total of 14 days. After monitored for 48 hours for the Jarisch-Herxheimer reaction he was discharged. No vision recovery on the left eye was noted at the time of discharge, however, the headache and eye pain had resolved.