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Satomi Konno1, Takuya Kishi2*, Hideyuki Kashiwagi3, Takehiko Makino3 and Takeyuki Matsuguchi1
2Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Japan
3Department of Palliative Care, Aso-Iizuka Hospital, Japan
Received date: September 23, 2014; Accepted date: November 13, 2014; Published date: November 22, 2014
Citation: Konno S, Kishi T, Kashiwagi H, Makino T, Matsuguchi T (2014) New Scoring System Available at Home Health Care for Prediction of 14 Days Survival in Lung Cancer Complicated with Lymphangitic Carcinomatosis. J Palliat Care Med 4:200. doi:10.4172/2165-7386.1000200
Copyright: © 2014 Konno S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Objective: Patients with lung cancer often greeted their terminal phase in the treatment at home, and many
cases complicated with lymphangitic carcinomatosis took a sudden turn. The aim of the present study was to
determine a scoring system available at home health care for prediction of short-term survival of lung cancer
complicated with lymphangitic carcinomatosis.
Methods: In 14 lung cancer patients with lymphangitic carcinomatosis in our medical care at home, we
determined significant close correlated and independent factors for assuming death during 14 days by logisticregression
analysis, and made out new scoring system. Moreover, we determined cut-off value on receiveroperating
characteristics analysis.
Results: In our scoring system calculated as the summation points awarded for the presence of 5 parameters
(i.e., systolic blood pressure<90 mmHg, 2 point; pulse rate>100 beats/minute, 3 point; blood oxygen
saturation<90%, 3 point; oxygen dose>2 L/minute, 2 point; respiratory frequency>20 times/minute, 3 point), cut-off
value was 8 (sensitivity 90%, specificity 68%).
Conclusions: We made a new a scoring system available at home health care for prediction of 14 days survival
of lung cancer complicated with lymphangitic carcinomatosis assumed systolic blood pressure, pulse rate,
respiratory frequency, blood oxygen saturation, and oxygen dose.
Lung cancer; Lymphangitic carcinomatosis; Home health care; Survival
Background
In our Iizuka city at Japan, aging has suddenly advances, because of lacking alternate industries for traditional coal industry. Moreover, we have so many households including only elderly people, as symbolizing the Japanese community, and it is necessary to do the home health care for end-stage illness, especially malignant cancer. In the aspect of home health care for end-stage, the remained survival would provide important and indispensability information to patients, patients’ family, and physicians. Lynn et al. showed that the end-of-life course varied according to disease (senility, heart failure, respiratory failure, and cancer) [1]. Among the diseases, in cancer, survival would be suddenly deteriorated by the decompensated general body function, although body function is relatively maintained until several months before death. Considering these backgrounds, prediction of survival in short term is necessary as clinical commitment for clinicians of oncology and palliative care to produce the meaningful remained days without excess anxiety for patients and to avoid inappropriate treatments [2].
Previous studies have already established the objective prediction for survival in patients with end-stage malignant cancer [3-8]. Maltoni et al. indicated that clinical survival prediction (clinical prediction of survival (CPS)) and prognostic scores are recommended (level A) based on evidence in the prognostic correlation within 90 days [3]. Stone et al. discussed Palliative Prognostic Score (PaP), Palliative Prognostic Index (PPI), terminal cancer prognostic (TCP) score, Bruera poor prognostic indicator, and Chuang prognositic score (CPS), and concluded that the prognostic scales offer an improvement on unadjusted clinician estimates of survival, in spite of several limitations [3-8]. The PPI established as an objective 3 weeks prognosis estimated evaluation of the cancer in terminal phase is available at home health care without drawing blood. Interestingly, recent paper suggested that Prognosis in Palliative care Study without blood results could be performed as well as clinician’ estimates of survival [9].
Lung cancer is most common in patients with cancer in our country. Therefore, patients with lung cancer often greeted their terminal phase in the treatment at home health care. At the start of the present study, we consecutively experienced the sudden and not anticipated death of lymphangitic carcinomatosis in such a period. However, we have no methods available at home health care to predict short-term survival of such patients. Therefore, the aim of the present study was to determine a scoring system available at home health care for prediction of short-term survival of lung cancer complicated with lymphangitic carcinomatosis.
Among the patients who took home health care of Matsuguchi Clinic between January 2010 and December 2012, 14 consecutive lung cancer patients with lymphangitic carcinomatosis were retrospectively enrolled. We defined 15 days survival as the primary outcome. Clinical parameters at the first visit to patient’s home after the initiation of home health care by out clinic were assessed, because out motivation was to determine the predictive tool of short-term survival at the first visit to patient’s home. Continuous variables were compared by unpaired t-test. Categorical variables were compared by Fischer’s exact test. Univariate and multivariate analysis with a logistic regression model were done to calculate adjusted odds ratio (OR) and 95% confidence interval (CI) to assess the influence of each variable to 15 days survival. Significant variables in the univariate analysis were assessed in the multivariable analysis. Weighed scores were allocated to each selected variable on the basis of each OR, and we made a new scoring system. Moreover, a cut-off point was obtained by receiver-operating characteristic (ROC) analysis with SPSS(SPSS Inc., Chicago, IL, U.S.A.). A ROC curve was made by which the area under the curve (AUC) for the score was calculated. All data are expressed as mean ± standard deviation. Significance was regarded as P<0.05. The present study complied with the Declaration of Helsinki. Informed consent was obtained from all patients before enrollment.
Among the enrolled 14 patients (10 males and 4 females, mean age was 67 ± 3 years), 6 patients (5 males and 1 female, mean age was 69 ± 5 years) died within 15 days at home. Table 1 showed the clinical parameters at the first visit to patient’s home after the initiation of home health care by out clinic.
| Deathwithin 15 days(n=6) | Survivalover 15 days(n=8) | Total(n=14) | |
|---|---|---|---|
| Age (years old) | 69 ± 5 | 66 ± 3 | 67 ± 3 |
| SBP (mmHg) | 92 ± 18* | 112 ± 19 | 105 ± 24 |
| DBP (mmHg) | 61 ± 6 | 64 ± 11 | 63 ± 9 |
| Heart rate (bpm) | 98 ± 21* | 84 ± 19 | 89 ± 20 |
| SpO2 (%) | 90 ± 3* | 94 ± 4 | 92 ± 5 |
| O2 (L/min) | 4 ± 2* | 2 ± 1 | 2 ± 1 |
| RF (times/min) | 24 ± 3* | 19 ± 4 | 21 ± 6 |
| Body temperature | 37 ± 2 | 37 ± 1 | 37 ± 1 |
| Body weights (kg) | 54 ± 9 | 57 ± 6 | 58 ± 8 |
Table 1: *P<0.05 vs. patients with survival over 15 days (SBP: systolic blood pressure; DBP: diastolic blood pressure; bpm: beats per minute; RF: respiratory frequency).
In the univariable analysis, a significant difference was found in systolic blood pressure<90 mmHg, pulse rate>100 beats/minute, blood oxygen saturation<90%, oxygen dose>2 L/minute, respiratory frequency>20 times/minute (Table 2). According to the multivariable analysis, systolic blood pressure<90 mmHg, pulse rate>100 beats/minute, blood oxygen saturation<90%, oxygen dose>2 L/minute, respiratory frequency>20 times/minute were independent factors for 14 days survival (Table 2).
| UnivariateP | Multivariate odds ratio (95% CI) | P | |
|---|---|---|---|
| Age | 0.88 | ||
| Sex | 0.19 | ||
| Metastasis | 0.13 | ||
| SBP<90 mmHg | 0.01 | 1.69 (1.32-2.04) | 0.01 |
| DBP<60 mmHg | 0.19 | ||
| HR>100 bpm | 0.02 | 2.57 (2.11-2.98) | 0.03 |
| SpO2<90% | 0.05 | 2.88 (2.45-3.27) | 0.03 |
| O2>2 L/min | 0.01 | 1.82 (1.27-2.39) | 0.04 |
| Body temperature | 0.17 | ||
| Respiratory frequency>20/min | 0.04 | 2.52 (1.99-3.10) | 0.03 |
Table 2: Univariate and Multivariate analysis (SBP: systolic blood pressure; DBP: diastolic blood pressure; HR: heart rate; bpm: beats per minute).
Considering the results of multivariate logistic analysis, systolic blood pressure<90 mmHg, pulse rate>100 beats/minute, blood oxygen saturation<90%, oxygen dose>2 L/minute, respiratory frequency>20 times/minute were selected to our new scoring system, calculated as the summation points awarded for the presence of 5 parameters (ie, systolic blood pressure<90 mmHg (OR 1.69), 2 point; pulse rate>100 beats/minute (OR 2.57), 3 point; blood oxygen saturation<90% (OR 2.88), 3 point; oxygen dose>2 L/minute (OR 1.82), 2 point; respiratory frequency>20 times/minute (OR 2.52), 3 point). ROC analysis revealed that cutoff value was 8 (90% of sensitivity, specificity 68%) (Figure 1).
Figure 1: ROC curve of our scoring system for the prediction of 14 days survival of lung cancer with lymphangitis carcinomatosis. Sensitivity and specificity of each cutoff points are shown.
In the present study, we made a new a scoring system for prediction of 14 days survival of lung cancer complicated with lymphangitic carcinomatosis assumed systolic blood pressure, pulse rate, respiratory frequency, blood oxygen saturation, and oxygen dose. Cut-off value of summation points awarded for the presence of 5 parameters (systolic blood pressure<90 mmHg, 2 point; pulse rate>100 beats/minute, 3 point; blood oxygen saturation<90%, 3 point; oxygen dose>2 L/minute, 2 point; respiratory frequency>20 times/minute, 3 point) was 8 (90% of sensitivity, specificity 68%) by ROC analysis.
Previous many studies have demonstrated that the survival of malignant cancer can be predicted significantly by decrease in false cholinesterase [3,10], increase in vitamin B12 [3,11], increase in serum bilirubin [3,12] with multivariate analysis and increase in C-reactive protein [3,11,13], decrease in lymphocytes [3,5,10], and increase in leukocytosis [5,10] statistically. However, these parameters are assessed by blood sample, and are not easily used in home health care. In these aspects, our present results and scoring system have clinical implications. Furthermore, it will be certain that wearing devices of body monitoring would spread by medical innovation in future, and the present scoring system could be calculated automatically at home health care by the future wearing medical devices without the visiting of medical staff.
The present study is just only a biased retrospective assessment at a single center, and the statistic power is not so high. Moreover, the sample size per 3 years was small, because we focused only lymphangitic carcinomatosis, which is not major in lung cancer overall. Not only lymphangitic carcinomatosis, the patients who had advanced stages of lung cancer could have suffered from many kinds of symptoms and conditions. Moreover, we used the parameters only assessed at the first visit to patient’s home after the initiation of home health care by out clinic, because out motivation was to determine the predictive tool of short-term survival at the first visit to patient’s home. We did not assess the time course of clinical parameters as predictive value. Considering these limitations, we could not provide our scoring system as a useful definitive predictive tool in clinical practice for lung cancer from only the present results.
The study’s greatest strength is that we tried to make a new and potentiated scoring system available at home health care for prediction of 14 days survival of lung cancer complicated with lymphangitic carcinomatosis assumed systolic blood pressure, pulse rate, respiratory frequency, blood oxygen saturation, and oxygen dose. Next future prospective large and multi-center studies are necessary to determine whether our concept would be really useful in clinical practice for lung cancer.
The Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, is supported by Otsuka Pharma and Nippon Boehringer Ingelheim (to Dr. Kishi). We would like to make special thanks to all the medical staff of Matsuguchi Clinic.
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