Toxicology: Open Access
Open Access

Nanotechnology involves the manipulation of materials at the nanoscale, typically ranging from 1 to 100 nanometers in size. Nanomaterials exhibit unique physical, chemical, and biological properties compared to their bulk counterparts, making them attractive for various applications. However, concerns have been raised about the potential adverse effects of nanomaterials on human health and the environment. Nano toxicology seeks to address these concerns by investigating the toxicity mechanisms, exposure routes, and risk factors associated with nanomaterials. Nanotechnology, the manipulation of materials at the nanoscale, has revolutionized various industries, from electronics to healthcare, offering unprecedented opportunities for innovation and advancement. However, the rapid proliferation of nanomaterials raises concerns about their potential impact on human health and the environment. Nano toxicology, the interdisciplinary field dedicated to studying the adverse effects of nanomaterials, plays a pivotal role in understanding the risks and implications of nanomaterial exposure. Nanomaterials, characterized by their unique properties such as small size, high surface area to volume ratio, and enhanced reactivity, exhibit distinct behaviors compared to their bulk counterparts. These properties confer novel functionalities that are desirable for numerous applications, yet they also pose challenges regarding their safety. The intricate interactions between nanomaterials and biological systems raise questions about their potential toxicity mechanisms, exposure routes, and long-term effects. In recent years, the scientific community has intensified efforts to unravel the complexities of nano toxicology and address emerging concerns. Studies have highlighted the diverse toxicological profiles of nanomaterials, ranging from respiratory and cardiovascular effects to genotoxicity and carcinogenicity. Moreover, the widespread use of nanomaterials in consumer products, industrial processes, and medical applications underscores the urgency of assessing their risks and implementing effective regulatory measures. This review aims to provide a comprehensive overview of nano toxicology, focusing on the risks and implications of nanomaterial exposure. By examining the current state of knowledge regarding nano toxicity, we seek to enhance understanding of the potential hazards associated with nanomaterials and facilitate informed decision-making in research, industry, and policy. Ultimately, a thorough grasp of nano toxicology is essential for ensuring the safe and responsible development of nanotechnology, maximizing its benefits while minimizing its risks to society and the environment [1-4].

Methodology

Characteristics of nanomaterials

Nanomaterials possess distinct properties such as high surface area to volume ratio, quantum effects, and enhanced reactivity. These properties can influence their behavior in biological systems and interactions with living organisms. Common types of nanomaterials include nanoparticles, nanotubes, nanofibers, and quantum dots, each with unique physicochemical properties that affect their toxicity profiles.

Potential hazards of nanomaterials

Several factors contribute to the potential hazards of nanomaterials, including their size, shape, surface chemistry, and surface charge. Nanoparticles can penetrate biological barriers such as the skin, respiratory tract, and gastrointestinal tract, leading to systemic distribution and accumulation in various organs. Moreover, nanomaterials may induce oxidative stress, inflammation, genotoxicity, and immunotoxicity, potentially resulting in adverse health effects such as respiratory disorders, cardiovascular diseases, and cancer [5-7].

Mechanisms of nano toxicity

The mechanisms underlying nano toxicity are complex and may involve multiple pathways. Key mechanisms include oxidative stress, inflammation, apoptosis, autophagy, and genotoxicity. Nanomaterials can generate reactive oxygen species (ROS) and disrupt cellular homeostasis, leading to cellular damage and dysfunction. Additionally, nanomaterials may interact with biomolecules such as proteins, lipids, and DNA, altering their structure and function.

Approaches for risk assessment and management

Effective risk assessment and management strategies are essential for ensuring the safe use of nanomaterials. These include physicochemical characterization, exposure assessment, hazard identification, dose-response analysis, and risk characterization. Furthermore, the implementation of engineering controls, personal protective equipment, and regulatory measures can minimize exposure to nanomaterials and mitigate associated risks [8-10].

Conclusion

Nano toxicology plays a crucial role in evaluating the safety and environmental impact of nanomaterials. By elucidating the mechanisms of nano toxicity and assessing associated risks, researchers can develop strategies to minimize potential harm while maximizing the benefits of nanotechnology. Continued research efforts are needed to advance our understanding of nano toxicology and ensure the responsible development and application of nanomaterials.

1. Sato N, Yoshiike N (2011) Dietary patterns affect occlusal force but not masticatory behavior in children. J Nutr Sci Vitaminol(Tokyo) 57: 258-264.

Indexed at, Google Scholar, Crossref

2. Takimoto H, Sarukura N, Ishikawa-Takata K (2015) How to define family meals in ‘Shokuiku’ (Food and Nutrition Education). J Nutr Sci Vitaminol (Tokyo) 61: 10-12.

Indexed at, Google Scholar, Crossref

3. Sawyer SM, Afifi RA, Bearinger LH, Blakemore SJ, Dick B, et al. (2012) Adolescence: a foundation for future health. Lancet 379: 1630-1640.

Indexed at, Google Scholar, Crossref

4. Lubans D, Richards J, Hillman C, Faulkner G, Beauchamp M, et al. (2016) Physical activity for cognitive and mental health in youth: a systematic review of mechanisms. Pediatrics 138: 20161642.

Indexed at, Google Scholar, Crossref

5. Doi Y, Ishihara K, Uchiyama M (2014) Reliability of the strengths and difficulties questionnaire in Japanese preschool children aged 4-6 years. J Epidemiol 24: 514-518.

Indexed at, Google Scholar, Crossref

6. Matsuishi T, Nagano M, Araki Y, Tanaka Y, Iwasaki M, et al. (2008) Scale properties of the Japanese version of the Strengths and Difficulties Questionnaire (SDQ): a study of infant and school children in community samples. Brain Dev 30: 410-415.

Indexed at, Google Scholar, Crossref

7. Fulkerson JA, Story M, Mellin A, Leffert N, Neumark-Sztainer D, et al. (2006) Family dinner meal frequency and adolescent development: relationships with developmental assets and high-risk behaviors. J Adolesc Health 39: 337-345.

Indexed at, Google Scholar, Crossref

8. Eisenberg ME, Olson RE, Neumark-Sztainer D, Story M, Bearinger LH (2004) Correlations between family meals and psychosocial well-being among adolescents. Arch Pediatr Adolesc Med 158: 792-796.

Indexed at, Google Scholar, Crossref

9. Sugiyama S, Okuda M, Sasaki S, Kunitsugu I, Hobara T (2012) Breakfast habits among adolescents and their association with daily energy and fish, vegetable, and fruit intake: a community-based cross-sectional study. Environ Health Prev Med 17: 408-414.

Indexed at, Google Scholar, Crossref

10. Kusano-Tsunoh A, Nakatsuka H, Satoh H, Shimizu H, Sato S, et al. (2001) Effects of family-togetherness on the food selection by primary and junior high school students: family-togetherness means better food. Tohoku J Exp Med 194: 121-127.

Indexed at, Google Scholar, Crossref