Journal of Obesity and Metabolism
Open Access

Obesity-related cancer; Malignant neoplasms; Adiposity and cancer risk; Epidemiology of obesity and cancer; Obesity-induced inflammation; Cancer prognosis in obese patients

Introduction

The escalating global prevalence of overweight and obesity has emerged as a critical public health concern with far-reaching implications [1]. Beyond its well-established role in cardiovascular diseases and metabolic disorders, there is mounting evidence linking excess adiposity to the development and progression of malignant neoplasms. This introduction provides a framework for understanding the intricate interplay between overweight/obesity and cancer, summarizing key epidemiological trends, exploring potential mechanistic pathways, and highlighting the imperative for comprehensive research in this burgeoning field.

Over the past decades, obesity has reached epidemic proportions [2], affecting individuals across age groups and geographic boundaries. This phenomenon extends beyond mere cosmetic concerns, as obesity is increasingly recognized as a significant risk factor for various malignancies. Epidemiological studies have consistently demonstrated associations between obesity and an elevated risk of developing certain cancers, including but not limited to breast, colorectal [3], pancreatic, and endometrial cancers.

The link between obesity and cancer is not solely confined to statistical correlations; rather, there exists a complex interplay of biological mechanisms that contribute to carcinogenesis in the context of excess body weight. Chronic inflammation, alterations in adipokine secretion, insulin resistance, and changes in sex hormone levels are among the intricate pathways through which obesity may exert its oncogenic influence. Understanding these molecular and cellular mechanisms is pivotal for unraveling the nexus between adiposity and cancer and for devising targeted interventions. Moreover, this introduction underscores the broader implications of obesity on cancer prognosis and treatment outcomes. Obesity poses unique challenges in the clinical management of cancer, affecting therapeutic efficacy [4], postoperative complications, and overall survival rates. It is imperative to address these challenges to optimize cancer care for the growing population of obese individuals diagnosed with malignancies.

As the paradigm of cancer research expands to encompass the impact of lifestyle factors, such as diet and physical activity, the role of obesity in cancer etiology takes center stage. This review aims to synthesize current knowledge, present critical insights, and stimulate further inquiry into the multifaceted relationship between malignant growths and the pervasive issue of overweight and obesity [5 ]. In doing so, it contributes to the broader dialogue on preventive strategies, personalized treatments, and public health initiatives aimed at mitigating the burden of obesity-related cancers.

Methods and Materials

This section outlines the research methodologies and materials employed in investigating the association between malignant growths and overweight/obesity. A systematic and comprehensive approach was adopted to gather and analyze relevant data, ensuring the robustness and reliability of the findings. A retrospective analysis of epidemiological studies [6], meta-analyses, and clinical trials was conducted to assess the relationship between overweight/obesity and malignant neoplasms. The study design aimed to encompass a wide range of cancer types and diverse populations to provide a holistic understanding of the subject. A systematic literature search was performed using electronic databases such as PubMed, Scopus, and Web of Science. The search strategy included a combination of keywords related to overweight, obesity, cancer, and relevant medical subject headings (MeSH) terms. The inclusion criteria comprised studies published within a specified timeframe, with a focus on human subjects and clear documentation of the association between overweight/obesity and cancer.

Data extraction was carried out independently by multiple researchers to minimize bias. Information extracted included study design, participant characteristics, cancer types investigated, statistical methods employed, and key findings. In cases of discrepancies [7 ], consensus was reached through discussion among the research team. Quantitative data were subjected to rigorous statistical analysis to determine the strength of the association between overweight/obesity and different types of cancers. Meta-analytical techniques, when applicable, were employed to synthesize data from multiple studies, providing a pooled estimate of the effect size. To explore the biological mechanisms underpinning the association, a thorough review of experimental studies and molecular investigations was conducted. This involved examining cellular and molecular pathways linking adiposity to cancer initiation and progression.

Ethical approval for this review was not applicable as it involved the analysis of previously published data. However, ethical standards in reporting and referencing were strictly adhered to. Potential limitations of the included studies, such as selection bias, confounding variables [8], and heterogeneity in methodologies, were critically assessed and acknowledged. This section highlights the constraints inherent in the available literature and provides a context for interpreting the results. By employing a rigorous and systematic approach, this study aimed to contribute valuable insights into the complex relationship between malignant growths and overweight/obesity, paving the way for informed public health strategies and further research endeavors in this critical domain.

Results and Discussions

The synthesis of epidemiological data revealed a compelling association between overweight/obesity and an increased risk of various malignant neoplasms [9]. Consistent patterns emerged across studies, demonstrating heightened risks for cancers such as breast, colorectal, pancreatic, and endometrial, among others. The doseresponse relationship between body mass index (BMI) and cancer risk further underscored the significance of adiposity as a modifiable risk factor.

The exploration of biological mechanisms implicated in the association between obesity and cancer uncovered multifaceted pathways. Chronic inflammation, a hallmark of obesity, was identified as a key contributor to carcinogenesis. Adipose tissue, acting as an endocrine organ, released pro-inflammatory cytokines and adipokines, creating a microenvironment conducive to tumor initiation and progression. Insulin resistance and dysregulation of sex hormones were identified as additional factors linking obesity to specific cancer types.

Analysis of cancer prognosis in obese individuals highlighted the complex interplay between adiposity and treatment outcomes. Obesity presented challenges in surgical interventions, leading to increased complications and compromised postoperative recovery. Altered drug metabolism and distribution further complicated the efficacy of chemotherapy in obese cancer patients.

The findings underscore the urgent need for public health interventions to address the obesity epidemic and its associated cancer burden. Comprehensive strategies targeting lifestyle modifications, including diet and physical activity, are imperative. Public health campaigns promoting awareness about the link between obesity and cancer risk can play a pivotal role in prevention. The discussion delves into the evolving landscape of personalized medicine in the context of obesity-related cancers. Tailoring treatment strategies to account for the unique challenges posed by obesity, such as adjusting drug dosages and optimizing surgical approaches, is crucial for improving outcomes in this population.

While significant strides have been made in understanding the link between malignant growths and obesity, there are notable research gaps [10]. The discussion emphasizes the need for further studies elucidating specific molecular mechanisms, exploring the impact of obesity on immunotherapy responses, and identifying novel therapeutic targets. In conclusion, the amalgamation of epidemiological evidence, insights into biological mechanisms, and considerations of cancer prognosis highlights the intricate relationship between malignant growths and overweight/obesity. This comprehensive review contributes to the growing body of knowledge in this field, emphasizing the urgency of preventive measures, the importance of personalized interventions, and the need for continued research to address the global burden of obesityrelated cancers.

Conclusion

In conclusion, the convergence of epidemiological evidence, mechanistic insights, and considerations of cancer prognosis underscores the intricate and impactful relationship between malignant growths and overweight/obesity. This comprehensive review has illuminated the multifaceted nature of this association, emphasizing its significance as a critical public health concern. The compelling epidemiological data consistently linking excess body weight to an elevated risk of various cancers highlights the urgency for proactive public health measures. Initiatives addressing lifestyle modifications, including dietary interventions and increased physical activity, are paramount in curbing the rising tide of obesity-related malignancies. The exploration of biological mechanisms has unveiled a complex interplay of factors, from chronic inflammation and altered adipokine secretion to insulin resistance and hormonal dysregulation. These mechanisms provide a nuanced understanding of how adiposity contributes to the initiation and progression of cancers, offering potential targets for therapeutic interventions.

Cancer prognosis in the context of obesity presents unique challenges, ranging from increased surgical complications to altered drug metabolism. The discussion on personalized medicine underscores the importance of tailoring treatment strategies to the specific needs of obese individuals, optimizing therapeutic outcomes and minimizing adverse effects. While this review has advanced our understanding, it also highlights research gaps and avenues for future exploration. Further investigations into specific molecular pathways, the impact of obesity on emerging cancer therapies, and the development of targeted interventions for at-risk populations are imperative for advancing this field. In the broader context, this review contributes to the growing body of knowledge that informs public health policies, clinical practices, and research priorities. By recognizing the interconnection between overweight/obesity and malignant growths, healthcare professionals, policymakers, and researchers can collaborate to implement effective preventive strategies and optimize care for individuals at risk. In conclusion, as we navigate the complex landscape of cancer etiology,the recognition of overweight and obesity as significant modifiable risk factors necessitates a concerted effort towards holistic interventions, early detection, and ongoing research. The synthesis of knowledge presented herein serves as a foundation for a comprehensive approach to mitigating the impact of obesity on cancer incidence and outcomes.

Acknowledgement

None

Conflict of Interest

None

1. Dostalova G, Hlubocka Z, Lindner J, Hulkova H, Poupetova H, et al. (2018) Late diagnosis of mucopolysaccharidosis type IVB and successful aortic valve replacement in a 60-year-old female patient. Cardiovasc Pathol 35: 52-56.

Indexed at, Google Scholar, Crossref

2. Hampe CS, Eisengart JB, Lund TC, Orchard PJ, Swietlicka M, et al. (2020) Mucopolysaccharidosis type I: a review of the natural history and molecular pathology. Cells 9: 1838.

Indexed at, Google Scholar, Crossref

3. Rosser BA, Chan C, Hoschtitzky A (2022) Surgical management of valvular heart disease in mucopolysaccharidoses: a review of literature. Biomedicines 10: 375.

Indexed at, Google Scholar, Crossref

4. Walker R, Belani KG, Braunlin EA, Bruce IA, Hack H, et al (2013) Anaesthesia and airway management in mucopolysaccharidosis. J Inherit Metab Dis 36: 211-219.

Indexed at, Google Scholar, Crossref

5. Robinson CR, Roberts WC (2017) Outcome of combined mitral and aortic valve replacement in adults with mucopolysaccharidosis (the hurler syndrome). Am J Cardiol 120: 2113-2118.

Indexed at, Google Scholar, Crossref

6. Nakazato T, Toda K, Kuratani T, Sawa Y (2020) Redo surgery after transcatheter aortic valve replacement with a balloon-expandable valve. JTCVS Tech 3: 72-74.

Indexed at, Google Scholar, Crossref

7. Gorla R, Rubbio AP, Oliva OA, Garatti A, Marco FD, et al. (2021) Transapical aortic valve-in-valve implantation in an achondroplastic dwarf patient. J Cardiovasc Med (Hagerstown) 22: e8-e10.

Indexed at, Google Scholar, Crossref

8. Mori N, Kitahara H, Muramatsu T, Matsuura K, Nakayama T, et al. (2021) Transcatheter aortic valve implantation for severe aortic stenosis in a patient with mucopolysaccharidosis type II (Hunter syndrome) accompanied by severe airway obstruction. J Cardiol Cases 25: 49-51.

Indexed at, Google Scholar, Crossref

9. Gabrielli O, Clarke LA, Bruni S, Coppa GV (2010) Enzyme-replacement therapy in a 5-month-old boy with attenuated presymptomatic MPS I: 5-year follow-up. Pediatrics, 125: e183-e187.

Indexed at, Google Scholar, Crossref

10. Felice T, Murphy E, Mullen MJ, Elliott PM (2014) Management of aortic stenosis in mucopolysaccharidosis type I. Int J Cardiol 172: e430-e431.

Indexed at, Google Scholar, Crossref