Graphene and Carbon Nanotubes Used as Electrode Modifiers for Pharmaceutical Drug Sensors
Received: 03-Oct-2017 / Accepted Date: 04-Oct-2017 / Published Date: 11-Oct-2017
Introduction
Graphene (GP) and Carbon nanotubes (CNTs) are the up-to-theminute materials used presently in the nanoscience and nanotechnology field. These nanomaterial’s are attractive materials in electrochemistry and fascinated strong scientific, technological interest in the recent years because of having high thermal conductivity, more surface area and having outstanding ability to mediate fast electron transfer kinetics for a wide range of electro active species these property made these nanomaterial's in wide applications, specifically in the Biosensors and Pharmaceutical drug sensors (electrochemical sensors) fields [1,2]. In general CNTs classified in to SWCNTs (Single), DWCNTs (Double), MWCNTs (Multiwalled) and there is a new category called functionalized CNTs based on the structures. Similarly the Graphene and Graphene Oxide are hottest materials in the nanotechnology field due to their excellent chemical properties.
In recent years these materials were attracted more in electrochemical field and used for the modified electrodes for the detection of pharmaceutical drugs. In adding up the modified electrode were used in an electrochemical fields are high sensitive, rapid response and offers good recovery and has wide linear range with moderately low-priced and these sensing devices are growing rapidly in recent years in the field of electrochemical sensors. These graphene and carbon nanotube materials were used as a modifier for the electrode for sensing the drugs directly and eventually these materials were used for the nanocomposite preparation with polymers. For instance the Polyaniline and graphene oxide used for the electrochemical detection, the new type of polymer nanocomposite were prepared and utilized for the non steroidal drug detection in blood serum with good specificity levels [3].
As stated above, in the same manner graphene oxide and carbon nanotubes nanocomposites were prepared by simple dispersion techniques and using for the concurrent detection of multilevel drugs in the biological levels, there are so many articles are available in this category for instance Paracetamol and Dopamine drugs were quantified using the graphene oxide and carbon nanotubes modified electrodes [4].
The graphene and carbon nanotubes were chemically treated and new nanocomposite was prepared called Carboxyl-functionalized graphene oxide composite and these composites were used as modifiers for the glassy carbon electrodes in electrochemical field, further used for the detection of various nonsteroidal antiinflammatory drugs such as diclofenac [5]. In addition, these methods can be used in Hospitals and pharmaceutical industries in near future, because chromatographic methods were more time consuming methods compared to electrochemical methods. These carbon nanotubes are having fast electron transfer activity and used as a biosensor with metal oxides too, Zinc oxide modified electrodes with immobilization of haemoglobin used for the peroxide detection [6].
Hence, these nanomaterial's were playing a key role in recent years specially Pharmaceutical and clinical industry. And I could say that these tiny nanomaterials will change the new dimension in the world, it’s already started in many fields batteries, automobiles, electronics.
References
- Yuyan S, Jun W, Hong W, Jun AAIL, Yuehe L (2010) Gp based electrochemical sensors and biosensors: A review electroanalysis. J Electroanal 22: 1027-1036.
- Cheemalapati S, Devadas B, Chen SM (2014) Novel poly-l-lysine/carboxyl groups enriched graphene oxide modified electrode preparation, characterization and its applications for the electrochemical determination of meloxicam in pharmaceutical tablets and blood serum. Anal Methods 6: 8426-8434.
- Cheemalapati S, Karuppiah C, Chen SM (2014) Synthesis of poly-aniline/graphene nano-composite film for the determination of non-steroidal anti-inflammatory drug (NSAIDs) diclofenac in blood serum. Sci Adv Mater 6: 1760-1768.
- Cheemalapati S, Palanisamy S, Mani V, Chen SM (2013) Simultaneous electrochemical determination of dopamine and paracetamol on multiwalled carbon nanotubes/graphene oxide nanocomposite-modified glassy carbon electrode. J Talanta 117: 297-304.
- Karuppiah C, Cheemalapati S, Chen SM, Palanisamy S (2015) Carboxyl functionalized graphene oxide modified electrode for the electrochemical determination of non-steroidal anti-inflammatory drug diclofenac. Ionics 21: 231-238.
- Palanisamy S, Cheemalapati S, Chen SM (2012) Highly sensitive and selective hydrogen peroxide biosensor based on hemoglobin immobilized at multiwalled carbon nanotubes–zinc oxide composite Electrode. Anal Biochem 429:108-115.
Citation: Reddy SCJ (2017) Graphene and Carbon Nanotubes Used as Electrode Modifiers for Pharmaceutical Drug Sensors. J Mater Sci Nanomater 1: e106.
Copyright: © 2017 Reddy SCJ. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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