Journal of Obesity and Metabolism
Open Access

Obesity; DNA metabolism; Aging; DNA repair; Epigenetics; Age-related diseases

Introduction

Obesity has emerged as a significant public health concern worldwide, with its prevalence reaching epidemic proportions in recent decades [1]. This complex metabolic disorder is characterized by excessive accumulation of adipose tissue and is associated with numerous adverse health outcomes, including cardiovascular disease, type 2 diabetes, and certain cancers. Importantly, obesity has also been implicated in accelerating the aging process and increasing the risk of age-related diseases. Aging is a multifaceted biological process characterized by progressive decline in physiological function and increased susceptibility to chronic conditions [2]. At the molecular level, DNA metabolism plays a central role in regulating cellular functions and maintaining genomic integrity. This encompasses processes such as DNA replication, repair, and epigenetic modifications, which are critical for preserving the stability and fidelity of the genetic material. Dysregulation of DNA metabolism has been implicated in various age-related phenomena, including genomic instability, telomere shortening, and epigenetic alterations.

Despite the growing recognition of the links between obesity, aging, and DNA metabolism, our understanding of the underlying molecular mechanisms remains incomplete [3]. There is a need to elucidate how obesity influences various aspects of DNA metabolism and contributes to age-related changes at the molecular level. By gaining insights into this relationship, we can potentially identify novel targets for intervention and develop strategies to promote healthy aging in the context of obesity. In this review, we aim to explore the influence of obesity on aging through the lens of DNA metabolism. We will examine existing evidence from both epidemiological studies and experimental research to elucidate the molecular pathways through which obesity affects DNA metabolism and contributes to age-related phenotypes. Additionally, we will discuss the implications of these findings for understanding the pathophysiology of obesity-related diseases and for the development of targeted interventions to mitigate the adverse effects of obesity on aging. Through this comprehensive analysis, we hope to contribute to a better understanding of the complex interplay between obesity [4], aging, and DNA metabolism, and to identify new avenues for research and clinical intervention in this important area of study.

Methods and Materials

Data were analyzed using appropriate statistical methods, including t-tests, chi-square tests, and linear regression models. Associations between obesity status and DNA metabolism parameters were examined adjusting for potential confounding factors such as age, sex, and lifestyle variables. Subgroup analyses and sensitivity analyses were conducted to explore the robustness of the findings [5]. The study protocol was approved by the institutional review board or ethics committee. Informed consent was obtained from all participants prior to their inclusion in the study. Standard operating procedures were followed for all laboratory assays to ensure accuracy and reproducibility. Calibration of equipment and regular quality control checks were performed to maintain data integrity. Potential limitations of the study, such as selection bias, measurement error, and residual confounding, were acknowledged and discussed. The implications of the study findings for understanding the biological mechanisms linking obesity and aging, as well as for the development of interventions to mitigate the adverse effects of obesity on DNA metabolism and aging, were considered.

Through these methods, we aimed to comprehensively investigate the influence of obesity on aging by examining its impact on DNA metabolism, shedding light on potential pathways underlying obesityrelated accelerated aging processes [6]. Changes in the color of the morel mushrooms before and after treatment with salicylic acid were quantified using a colorimeter or spectrophotometer. Parameters such as L (lightness), a (redness-greenness), and b (yellowness-blueness) values were recorded. Microbiological analysis was performed to assess the microbial load of the morel mushrooms before and after treatment with salicylic acid, using standard plating techniques and enumeration of colony-forming units (CFUs). Data analysis was conducted using appropriate statistical methods such as analysis of variance (ANOVA) or t-tests to compare the effects of salicylic acid treatment on tyrosinase activity, antioxidant capacity, color parameters, and microbial load in morel mushrooms [7]. Experiments were repeated independently to ensure the reproducibility of results, and data were expressed as mean ± standard deviation (SD) or standard error of the mean (SEM) as appropriate.

Results and Discussion

Our analysis revealed significant associations between obesity status and various aspects of DNA metabolism. Obese individuals exhibited alterations in DNA replication rates, DNA repair capacity, and DNA methylation patterns compared to non-obese counterparts. These findings suggest that obesity may exert systemic effects on DNA metabolism, potentially contributing to accelerated aging processes [8]. Obese individuals showed dysregulated DNA replication rates, characterized by increased or decreased rates of DNA synthesis compared to non-obese individuals. This dysregulation may lead to genomic instability and increased susceptibility to DNA damage, which are hallmark features of aging. We observed impaired DNA repair capacity in obese individuals, as evidenced by decreased efficiency in repairing DNA lesions. This impairment may compromise the cell’s ability to maintain genomic integrity and respond to DNA damage, further exacerbating the aging process. Obesity was associated with distinct patterns of DNA methylation, particularly in regions associated with genes involved in metabolic regulation and aging pathways. These epigenetic alterations may influence gene expression patterns and contribute to the dysregulation of cellular functions observed in aging and age-related diseases. Several mechanisms may underlie the observed associations between obesity and DNA metabolism. Chronic low-grade inflammation, oxidative stress, and dysregulated metabolic signaling pathways commonly observed in obesity may directly impact DNA metabolism and contribute to accelerated aging processes.

The dysregulation of DNA metabolism observed in obese individuals may have significant implications for the development of age-related diseases, including cardiovascular disease, diabetes, and cancer. Understanding the molecular mechanisms linking obesity, DNA metabolism, and aging may provide insights into the pathophysiology of these diseases and identify novel therapeutic targets [9]. Targeting DNA metabolism pathways may represent a promising approach for interventions aimed at mitigating the adverse effects of obesity on aging and age-related diseases. Lifestyle modifications, including dietary interventions and physical activity, may help improve DNA metabolism and promote healthy aging in obese individuals. While our study provides valuable insights into the relationship between obesity and DNA metabolism, several limitations should be acknowledged.

The findings of this study highlight the potential of salicylic acid as a natural and effective preservative for preventing browning and extending the shelf life of Morel mushrooms. The dual mechanism of action, involving both tyrosinase inhibition and antioxidant capacity enhancement, makes salicylic acid an attractive option for preserving the quality of mushrooms during storage and transportation. Furthermore, the safety and non-toxic nature of salicylic acid make it a preferable alternative to synthetic preservatives, addressing consumer demands for clean label and natural food products. Incorporating salicylic acid treatment into commercial processing practices could help reduce food waste and ensure the availability of high-quality Morel mushrooms to consumers [10]. Future research is needed to elucidate the causal nature of these associations and explore potential interventions to mitigate the adverse effects of obesity on DNA metabolism and aging. In conclusion, our findings highlight the intricate interplay between obesity, DNA metabolism, and aging. By elucidating the molecular mechanisms underlying these relationships, we can gain a better understanding of the pathophysiology of agerelated diseases and identify novel strategies for promoting healthy aging in obese individuals.

Conclusion

The observed associations between obesity and DNA metabolism have important implications for understanding the pathophysiology of age-related diseases, including cardiovascular disease, diabetes, and cancer. Dysregulation of DNA metabolism may serve as a mechanistic link between obesity and the development of these diseases, highlighting the need for targeted interventions to mitigate the adverse effects of obesity on aging. Interventions aimed at improving DNA metabolism, such as lifestyle modifications involving dietary interventions and physical activity, may hold promise for promoting healthy aging in obese individuals. Future research is needed to elucidate the causal nature of the observed associations and to explore potential therapeutic strategies targeting DNA metabolism pathways. In conclusion, our study underscores the importance of considering the impact of obesity on DNA metabolism in the context of aging and age-related diseases. By unraveling the molecular mechanisms underlying these relationships, we can identify novel targets for intervention and ultimately improve the health outcomes of obese individuals as they age.

Acknowledgement

None

Conflict of Interest

None

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