Cervical Cancer: Open Access
Open Access

Venereal diseases; Sexually transmitted infections; Reproductive health; Infertility; Ectopic pregnancies; Miscarriages; HIV susceptibility; Early diagnosis; Public health; Prevention

Introduction

The relationship between venereal diseases (VDs), also referred to as sexually transmitted infections (STIs), and reproductive health has been a subject of intense study due to their profound impact on individuals’ physical well-being and societal health at large. STIs are transmitted through sexual contact and are among the most prevalent communicable diseases worldwide. They affect millions of individuals annually, with women and adolescents being especially vulnerable due to unique biological and sociocultural factors [1].

The effects of VDs on reproductive health are extensive, leading to challenges such as infertility, congenital malformations, increased maternal morbidity, and pregnancy complications. While many STIs can be effectively treated with antibiotics or antivirals, others, especially when left undiagnosed or untreated, can cause irreversible damage to the reproductive system. For individuals and couples wishing to start families, these complications can pose additional emotional, physical, and psychological burdens [2].

In recent years, increased awareness around the importance of sexual health education, regular screening, and safe sexual practices has helped reduce the incidence of some STIs. However, the connection between venereal diseases and reproductive health is not universally understood, and gaps in knowledge still remain, especially in terms of how these diseases exacerbate reproductive health concerns, particularly among those without access to healthcare. Therefore, it is vital to explore and understand this relationship to improve prevention, treatment, and intervention strategies [3].

Description

Venereal diseases (VDs) encompass a wide array of infections, including bacterial, viral, and parasitic pathogens. Among the most common STIs that impact reproductive health are chlamydia, gonorrhea, syphilis, trichomoniasis, herpes, human papillomavirus (HPV), and HIV. The incidence and severity of these diseases are subject to numerous variables, including social factors (e.g., lack of sexual education, multiple sexual partners, unprotected sex) and healthcare access.

Chlamydia and gonorrhea are two of the most frequently diagnosed STIs worldwide. Both are bacterial infections that, if untreated, can lead to pelvic inflammatory disease (PID) in women and cause scarring of the fallopian tubes, which may lead to infertility, ectopic pregnancies, and chronic pelvic pain. These diseases can also cause complications during pregnancy, including preterm birth, premature rupture of membranes, and low birth weight infants. The risk of transmission of these infections to newborns during delivery can result in neonatal conjunctivitis or pneumonia, which underscores the importance of early detection and treatment [4].

Syphilis, a bacterial STI caused by Treponema pallidum, is notorious for its various stages, from primary to tertiary. In its early stages, it presents as sores or ulcers, but if left untreated, it can progress to more serious complications affecting multiple organs, including the reproductive organs. Congenital syphilis is a particular concern during pregnancy, as it can lead to fetal death, miscarriage, or severe congenital defects. Prompt treatment with antibiotics during pregnancy is essential in preventing maternal-fetal transmission and ensuring favorable pregnancy outcomes [5].

Trichomoniasis, caused by the parasitic organism Trichomonas vaginalis, is one of the most common STIs, particularly among women. While the infection is often asymptomatic, it can result in vaginitis and an increased susceptibility to HIV. Women infected with trichomoniasis are at a higher risk of preterm delivery, low birth weight, and complications during labor. In men, trichomoniasis can lead to urethritis and discomfort, though reproductive complications are less common.

Herpes simplex virus (HSV) and human papillomavirus (HPV) are two viral STIs that can significantly impact reproductive health. HSV can cause painful sores and genital lesions, with periodic outbreaks that may be stressful for individuals. While the virus does not directly impair fertility, pregnant women with active herpes infections can transmit the virus to their newborns during childbirth, leading to neonatal herpes, which may be life-threatening [6].

HPV is a major cause of cervical cancer, which is one of the leading causes of death among women of reproductive age globally. Persistent HPV infections may lead to the development of precancerous lesions on the cervix, which, if untreated, can lead to cervical cancer. Vaccines available for HPV can reduce the risk of HPV-related cancers and reduce the impact on reproductive health [7-9].

Human Immunodeficiency Virus (HIV) significantly compromises the immune system and can result in Acquired Immunodeficiency Syndrome (AIDS) if left untreated. HIV complicates pregnancy, leading to higher rates of miscarriage, stillbirth, preterm birth, and low birth weight. Additionally, untreated HIV increases the risk of mother-to-child transmission during pregnancy, labor, or breastfeeding. Antiretroviral therapy (ART) during pregnancy, however, can significantly reduce the risk of transmission and improve maternal health [10].

Discussion

The connection between venereal diseases and reproductive health is both direct and indirect. Direct effects include the damage caused to the reproductive organs and systems, such as the fallopian tubes, cervix, uterus, and ovaries. Indirect effects include the psychosocial consequences of fertility problems, the strain of managing a chronic illness such as HIV, and the increased risk of other complications such as ectopic pregnancies.

Venereal diseases, through mechanisms such as inflammation, scarring, and chronic infections, can interfere with normal reproductive processes. For instance, the scarring of fallopian tubes due to untreated gonorrhea or chlamydia infections can block the passage of the egg, causing infertility. Additionally, the inflammatory response triggered by these infections can create an inhospitable environment for sperm or eggs, further complicating reproductive outcomes.

Reproductive health issues related to STIs are particularly pronounced during pregnancy. Untreated infections during pregnancy can have devastating consequences for both maternal and fetal health. For example, bacterial infections like chlamydia and syphilis increase the risk of miscarriage and stillbirth, while untreated HIV can lead to vertical transmission, affecting the newborn’s health. The complications that arise during pregnancy due to STIs not only require medical intervention but also have lasting psychological and economic effects on the families involved.

STIs also exacerbate the risks of other infections. For instance, individuals infected with HPV or herpes are more vulnerable to contracting HIV, as the genital lesions or other open wounds associated with these infections create a portal of entry for the virus. As a result, the overall burden of STIs increases, creating complex scenarios where reproductive health is severely compromised.

In light of these considerations, education, early detection, prevention strategies, and access to comprehensive healthcare are critical to reducing the burden of venereal diseases on reproductive health. Public health initiatives should focus on promoting safer sexual practices, such as condom use, regular STI screening, and the importance of timely medical intervention when infections occur.

Conclusion

The connection between venereal diseases and reproductive health is critical to understanding the broader impact of sexual health on individuals, couples, and populations. STIs, if left untreated, can lead to severe reproductive health consequences such as infertility, ectopic pregnancies, and complications during childbirth. In women, the consequences are often compounded by pregnancy-related issues that can result in significant morbidity for both the mother and the child. By fostering a public health environment that emphasizes prevention, early diagnosis, and comprehensive sexual health education, the adverse effects of venereal diseases on reproductive health can be mitigated.

The need for a multifaceted approach-incorporating education, better healthcare access, and timely medical interventions-remains key to improving reproductive outcomes for individuals affected by STIs. Continued research into the intersection of sexual health and reproductive health will guide the development of novel treatments and public health initiatives to safeguard the well-being of all, particularly vulnerable populations such as young women, adolescents, and pregnant individuals. Addressing venereal diseases in the context of reproductive health is not only crucial to ensuring fertility and positive pregnancy outcomes but also to improving overall quality of life and public health.

Acknowledgement

None

Conflict of Interest

None

1. Bakewell SJ, Nestor P, Prasad S, Tomasson MH, Dowland N, et al. (2003) Platelet and Osteoclast β 3 Integrins Are Critical for Bone Metastasis. Proc Natl Acad Sci USA 100: 14205-14210.

Indexed at, Google Scholar, Crossref

2. Baron R, Ferrari S, Russell R (2011) Denosumab and Bisphosphonates: Different Mechanisms of Action and Effects. Bone 48: 677-692.

Indexed at, Google Scholar, Crossref

3. Baselga J, Rothenberg ML, Tabernero J, Seoane J, Daly T, et al. (2008) TGF-β Signalling-Related Markers in Cancer Patients with Bone Metastasis. Biomarkers 13: 217 -236.

Indexed at, Google Scholar, Crossref

4. Cheng L, Shoma Suresh K, He H, Rajput RS, Feng Q, et al. (2021) 3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives. Int J Nanomed 16: 4289-4319.

Indexed at, Google Scholar, Crossref

5. Ciocca L, Lesci I, Ragazzini S, Gioria S, Valsesia A, et al. (2020) Nanostructured surface bioactive composite scaffold for filling of bone defects. Biointerface Res Appl Chem 10: 5038-5047.

Google Scholar, Crossref

6. Shieh Y, Hu D, Ma L (2016) Breast cancer risk prediction using a clinical risk model and polygenic risk score. Breast cancer research and treatment 159: 513-525.

Indexed at, Google Scholar, Crossref

7. Li FP, Fraumeni JF, Jr (1969) Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Annals int med 71: 747-752.

Indexed at, Google Scholar, Crossref

8. Mai PL, Malkin D, Garber JE (2012) Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium. Can genetics 205: 479-487.

Indexed at, Google Scholar, Crossref

9. Abu-Amer Y, Teitelbaum SL, Chappel JC, Schlesinger P, Ross FP, et al. (1999) Expression and Regulation of RAB3 Proteins in Osteoclasts and Their Precursors. J Bone Miner Res 14: 1855-1860.

Indexed at, Google Scholar, Crossref

10. Ahove DA, Hoffman KE, Hu JC, Choueiri TK, D'Amico AV, et al. (2010) Which Patients with Undetectable PSA Levels 5 Years after Radical Prostatectomy Are Still at Risk of Recurrence?-Implications for a Risk-Adapted Follow-Up Strategy. Urology 76: 1201-1205.

Indexed at, Google Scholar, Crossref