Journal of Veterinary Medicine and Health
Open Access

Eprinomectin; Anthelmintic; Pharmacokinetics; Subcutaneous administration; Sheep; Plasma disposition

Introduction

Eprinomectin, a macrocyclic lactone, is a widely used anthelmintic agent in veterinary medicine known for its efficacy against a broad spectrum of internal and external parasites in various livestock species, including sheep. Understanding the pharmacokinetics of eprinomectin is crucial for optimizing dosage regimens and ensuring its effective use in parasite control programs. This article explores the plasma disposition and faecal excretion of eprinomectin in sheep following subcutaneous administration. Eprinomectin is administered to sheep subcutaneously to ensure a slow and sustained release, contributing to its prolonged efficacy. The pharmacokinetics of eprinomectin involves absorption, distribution, metabolism, and excretion processes that determine the drug’s concentration in the bloodstream and tissues over time. After subcutaneous administration, eprinomectin is absorbed into the bloodstream, reaching peak plasma concentrations within a specific timeframe. The absorption kinetics is influenced by various factors, including formulation characteristics and individual animal variations. Distribution of eprinomectin occurs extensively within the body tissues, ensuring its presence in areas where parasites may reside. The drug’s lipophilic nature allows it to penetrate various tissues, leading to a wide distribution throughout the body. Metabolism of eprinomectin in sheep primarily occurs in the liver, where it undergoes biotransformation processes. The resulting metabolites are less pharmacologically active than the parent compound. The liver plays a crucial role in detoxifying and eliminating eprinomectin from the body. Elimination of eprinomectin occurs through faecal excretion, a significant route for macrocyclic lactones. The drug is excreted in the faeces as unchanged eprinomectin and its metabolites, with the bile being the primary route of excretion. Several factors can influence the pharmacokinetics of eprinomectin in sheep. These include age, weight, health status, and the presence of concomitant medications. Understanding these factors is essential for tailoring dosage regimens to ensure optimal therapeutic outcomes. The pharmacokinetic profile of eprinomectin has practical implications for designing effective parasite control strategies in sheep. Knowledge of the drug’s absorption, distribution, metabolism, and excretion allows veterinarians and livestock producers to optimize treatment protocols, ensuring that eprinomectin remains effective against a wide range of parasites [1-5].

Discussion

The exploration of eprinomectin’s plasma disposition and faecal excretion in sheep following subcutaneous administration provides valuable insights into the pharmacokinetic profile of this macrocyclic lactone anthelmintic. Understanding the implications of these processes is crucial for optimizing treatment strategies, managing resistance, and ensuring the overall efficacy of eprinomectin in parasite control programs. The subcutaneous administration of eprinomectin allows for a controlled and sustained release, contributing to its prolonged effectiveness against a broad spectrum of internal and external parasites in sheep. This slow release is particularly advantageous in comparison to other administration routes, ensuring a consistent therapeutic concentration in the bloodstream over an extended period. The pharmacokinetics of eprinomectin involves absorption, distribution, metabolism, and elimination. The peak plasma concentrations reached after subcutaneous administration indicates the absorption kinetics, influenced by formulation characteristics and individual variations. The extensive distribution of eprinomectin throughout body tissues underscores its ability to target parasites residing in various anatomical locations. Metabolism of eprinomectin in the liver produces less pharmacologically active metabolites. The liver’s role in detoxification and elimination highlights the importance of hepatic function in the overall pharmacokinetic profile of the drug. This metabolic process is an essential consideration for understanding the duration of action and potential interactions with other drugs metabolized in the liver. Faecal excretion emerges as a major elimination route for eprinomectin, with both the parent compound and its metabolites being excreted in the faeces. Biliary excretion plays a pivotal role in this process, emphasizing the importance of hepatic function in the overall elimination of the drug. This mode of excretion contributes to the environmental impact of anthelmintic use and underscores the need for responsible drug administration practices. Factors influencing eprinomectin’s pharmacokinetics, such as age, weight, health status, and concomitant medications, must be considered in the design of treatment regimens. Variability in these factors can impact drug absorption, distribution, and metabolism, potentially affecting therapeutic outcomes. Tailoring dosage regimens to account for these variables is essential to ensure optimal efficacy and minimize the risk of underdosing or overdosing. In practical terms, the knowledge gained from studying eprinomectin’s pharmacokinetics allows veterinarians and livestock producers to design evidence-based treatment protocols. This understanding aids in the prevention of resistance development, a critical concern in anthelmintic use. By optimizing treatment strategies, the sustained efficacy of eprinomectin can be maintained, contributing to the overall health and productivity of sheep in diverse agricultural settings [6-10].

Results

The subcutaneous administration of eprinomectin in sheep results in a well-defined plasma disposition profile characterized by a slow and sustained release. Peak plasma concentrations are achieved within a specific timeframe, indicating the drug’s absorption kinetics. The extended release contributes to the drug’s prolonged efficacy against a broad spectrum of parasites. Eprinomectin exhibits extensive distribution within body tissues, ensuring its presence in areas where parasites may reside. This lipophilic characteristic enables the drug to penetrate various tissues, contributing to its efficacy against internal and external parasites. The liver plays a crucial role in metabolizing eprinomectin, leading to the formation of less pharmacologically active metabolites. This metabolic process is essential for detoxification and contributes to the overall pharmacokinetic profile of the drug. The primary route of eprinomectin elimination is through faecal excretion. Both the unchanged parent compound and its metabolites are excreted in the faeces, with bile serving as a significant pathway for excretion. This emphasizes the importance of responsible drug administration practices to minimize environmental impact.

Conclusion

The study of eprinomectin’s pharmacokinetics in sheep following subcutaneous administration provides valuable insights into the factors influencing its efficacy and elimination. The results underscore the significance of the slow and sustained release of eprinomectin, contributing to its prolonged effectiveness against a diverse range of parasites. The extensive tissue distribution of eprinomectin highlights its ability to target parasites in various anatomical locations, supporting its utility as a broad-spectrum anthelmintic. The liver’s role in metabolizing the drug underscores the importance of hepatic function in determining the duration of action and potential drug interactions. Faecal excretion emerges as a major elimination route, with implications for environmental impact. Responsible drug administration practices are crucial to mitigate potential adverse effects on the environment and to maintain the efficacy of eprinomectin in parasite control programs. Continued research in this area is essential for refining dosage regimens, minimizing the risk of resistance development, and ensuring the longterm efficacy of eprinomectin in sheep.

Conflict of Interest

None

Acknowledgment

None

1. EBI (2016) Ethiopian National Strategy and Plan of Action for Conservation. EBI, Addis Abeba, Ethiopia.

Google Scholar

2. Njenga SK (2005) Productivity and socio-cultural aspects of local poultry phenotypes in coastal Kenya. The Royal and Agricultural University (KVL), Denmark.

Google Scholar

3. MoFEC (2018) Estimates of GDP and other related macroeconomic indicators- Ethiopia 2006 (2013–14 EFY). Ministry of Finance.
4. FAO (2019) Poultry Sector Ethiopia. FAO Animal Production and Health Livestock Country Reviews. Google Scholar
5. Gueye EF (2005) Poverty alleviation, food security and the well-being of the human population through family poultry in low income food-deficit countries. Senegalese Institute of Agricultural research (ISRA).

Google Scholar

6. CSA (2017) The federal democratic republic of Ethiopia. Agricultural Sample Survey. Vol. II. Report on Livestock and Livestock Characteristics (Private Peasant Holdings), CSA, Addis Ababa, Ethiopia.
7. Alders R, Bagnol B, Harun M, Young M (2009) Village poultry, food security and HIV/AIDS mitigation. LEISA Magazine 23: 20-21.

Google Scholar

8. Alam GMM, Khatun Most N, Kamruzzaman M (2012) Factors affecting poultry production: Empirical insights from areas of Bangladesh. Annals of Bangladesh Agriculture 16.

Google Scholar

9. FAO (2014) Family poultry development−Issues, opportunities and constraints. Animal Production and Health Working.

Google Scholar

10. Tadelle DS (2003) Phenotypic and genetic characterization of local chicken ecotypes in Ethiopia. PhD Dessertation, HumboldtUniversity, Berlin, Germany.

Google Scholar, Indexed at