Biomaterial in Repairmen of Intervertebral Discs
Received: 01-Mar-2024 / Manuscript No. jbtbm-24-130857 / Editor assigned: 04-Mar-2024 / PreQC No. jbtbm-24-130857(PQ) / Reviewed: 18-Mar-2024 / QC No. jbtbm-24-130857 / Revised: 21-Mar-2024 / Manuscript No. jbtbm-24-130857(R) / Accepted Date: 29-Mar-2024 / Published Date: 29-Mar-2024 QI No. / jbtbm-24-130857
Abstract
Intervertebral Disc (IVD) degeneration and associated spinal disorders pose significant challenges in modern healthcare, leading to debilitating pain and decreased quality of life for millions worldwide. Traditional treatment options often focus on symptom management rather than addressing the underlying cause, highlighting the need for innovative regenerative therapies. Biomaterials have emerged as promising candidates for IVD repair and regeneration, offering versatile platforms for delivering therapeutic agents, promoting tissue healing, and restoring biomechanical function.
Keywords
Bone defects; trauma; surgical procedures; autografts; allografts; Electroactive biomaterials
Introduction
Electroactive biomaterials possess inherent electrical properties or can be engineered to respond to electrical stimulation, mimicking the endogenous electric fields present during bone healing. These materials can modulate cellular behavior, including proliferation, differentiation, and matrix deposition, crucial for effective bone regeneration [1]. Various types of electroactive biomaterials, such as conductive polymers, ceramics, and composites, have been explored for their ability to promote osteogenic activity. These abstract reviews recent advances in the design and fabrication of electroactive biomaterials tailored for bone defect repair. Strategies for incorporating conductivity into biomaterial matrices, including doping with conductive agents or creating hierarchical structures, are discussed. Furthermore, the influence of electrical stimulation parameters, such as frequency, intensity, and waveform, on bone cell response and tissue regeneration is examined [2].
Description
In the realm of orthopedic medicine, addressing bone defects resulting from various causes such as trauma, disease, or surgical procedures remains a significant clinical challenge. While conventional treatments like autografts and allografts have been used, they come with inherent limitations such as donor site morbidity and limited availability [3]. However, recent advancements in biomaterials science have paved the way for innovative approaches to bone defect repair, with electroactive biomaterials emerging as a promising avenue. Electroactive biomaterials represent a class of materials that possess inherent electrical conductivity or can respond to electrical stimulation [4, 5]. They mimic the endogenous electrical cues present during natural bone healing processes, thereby influencing cellular activities critical for bone regeneration. These biomaterials can modulate the behavior of bone cells, including osteoblasts and osteoclasts, by promoting proliferation, differentiation, and extracellular matrix synthesis [6].
The design and fabrication of electroactive biomaterials for bone defect repair involve various strategies aimed at enhancing their conductivity and biological functionality [7]. Researchers have explored techniques such as doping biomaterial matrices with conductive agents like carbon nanotubes or graphene, as well as creating hierarchical structures to facilitate electron transfer and cell-material interactions. Additionally, the optimization of electrical stimulation parameters, such as frequency, intensity, and waveform, has been investigated to harness the full potential of these materials in promoting bone regeneration [9].
Combining electroactive biomaterials with other therapeutic modalities, such as growth factors, stem cells, or bioactive scaffolds, has shown synergistic effects in accelerating bone healing and tissue integration. These multifunctional approaches create a conducive microenvironment for cell recruitment, proliferation, and differentiation, ultimately leading to enhanced bone defect repair. Preclinical studies utilizing animal models have demonstrated the efficacy of electroactive biomaterials in promoting bone regeneration and functional recovery. These studies provide valuable insights into the mechanisms underlying the therapeutic effects of electroactive biomaterials and pave the way for their translation into clinical practice [10].
Conclusion
In conclusion, the utilization of electroactive biomaterials holds immense promise for revolutionizing the field of bone defect repair and orthopedic regenerative medicine. By integrating electrical and biological functionalities, these innovative materials provide a unique platform to address the challenges associated with conventional treatment modalities. Through modulation of cellular behavior and enhancement of bone regeneration processes, electroactive biomaterials offer a multifaceted approach to accelerate healing and promote tissue integration.
References
- Warnock JN, Al-Rubeai M (2006). Bioreactor systems for the production of biopharmaceuticals from animal cells. Biotechnol Appl Biochem 45:1-12.
- Harding MW, Marques LLR, Howard RJ (2009). Can filamentous fungi form biofilms? Trends Microbiol. 17: 475-480.
- Fukuda H (1995). Immobilized microorganism bioreactors. In Asenjo JA, Merchuk JC. Bioreactor system design. Marcel Dekker Inc, New York. 339-375.
- Gross R, Schmid A, Buehler K (2012).Catalytic biofilms: a powerful concept for future bioprocesses. In: Lear G, Lewis GD (eds) Microbial biofilms. 193-222.
- Kobayashi M, Shimizu S (2000). Nitrile hydrolases. Curr Opin Chem Biol. 4: 95-102.
- Murphy CD (2012). The microbial cell factory. Org Biomol Chem. 10:1949-1957.
- Crueger W, Crueger A, Brock TD (1990). Biotechnology. A textbook of industrial microbiology, 2nd edn. Sinauer Associates, Sunderland.
- Kersters K, Lisdiyanti P, Komagata K (2006). The family Acetobacteracea: the genera Acetobacter, Acidomonas, Asaia, Gluconacetobacter, Gluconobacter, and Kozakia. In: Dworkin M (ed) Prokaryotes, vol 5. Springer Science? Business Media, New York.163-200.
- Li XZ, Hauer B, Rosche B (2007). Single-species microbial biofilm screening for industrial applications. Appl Microbiol Biotechnol. 76:1255-1262.
- Cronenberg CCH, Ottengraf SPP, Vandenheuvel JC (1994). Influence of age and structure of penicillium chrysogenum pellets on the internal concentration profiles. Bioprocess Eng. 10: 209-216.
Indexed at, Google Scholar, Crossref
Indexed at, Google Scholar, Crossref
Indexed at, Google Scholar, Crossref
Indexed at, Google Scholar, Crossref
Indexed at, Google Scholar, Crossref
Citation: Gerick G (2024) Biomaterial in Repairmen of Intervertebral Discs. JBiotechnol Biomater, 14: 380.
Copyright: © 2024 Gerick G. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
Share This Article
Recommended Journals
Open Access Journals
Article Usage
- Total views: 72
- [From(publication date): 0-0 - Aug 17, 2024]
- Breakdown by view type
- HTML page views: 53
- PDF downloads: 19