Biomaterial Based on Silk Fibroin for the treatment of Musculoskeletal Diseases
Received: 01-Jan-2024 / Manuscript No. jbtbm-24-127054 / Editor assigned: 04-Jan-2024 / PreQC No. jbtbm-24-127054(PQ) / Reviewed: 25-Jan-2024 / QC No. jbtbm-24-127054 / Revised: 26-Jan-2024 / Manuscript No. jbtbm-24-127054(R) / Accepted Date: 30-Jan-2024 / Published Date: 31-Jan-2024
Abstract
Musculoskeletal diseases, encompassing a wide range of conditions affecting bones, cartilage, muscles, and connective tissues, present significant challenges in healthcare, often resulting in pain, loss of function, and reduced quality of life for patients. Regenerative medicine, particularly tissue engineering, has emerged as a promising approach for treating musculoskeletal disorders by utilizing biomaterials to promote tissue repair and regeneration. Among these biomaterials, silk fibroin has garnered considerable attention due to its unique properties and versatile applications. This abstract provides an overview of the potential of silk fibroin-based biomaterials in the treatment of musculoskeletal diseases.
Keywords
Musculoskeletal diseases; Regenerative medicine; Musculoskeletal disorders; Fibroin based biomaterials
Introduction
Silk fibroin, derived from the silkworm Bombyx mori, is a natural protein with exceptional mechanical properties, biocompatibility, and biodegradability. These properties make silk fibroin an attractive candidate for musculoskeletal tissue engineering, where the regeneration of complex tissues such as bone, cartilage, and tendon requires scaffolds that can mimic the native tissue microenvironment and support cellular growth and differentiation.
Description
In bone tissue engineering, silk fibroin-based scaffolds have been extensively studied for their ability to promote osteogenic differentiation of Mesenchymal Stem Cells (MSCs) and facilitate bone formation [1,2]. The porous structure and mechanical properties of silk fibroin scaffolds closely resemble those of native bone tissue, providing a supportive environment for cell adhesion, proliferation, and mineralization [3,4]. Furthermore, the incorporation of bioactive molecules, such as growth factors or osteoinductive agents, into silk fibroin matrices enhances their regenerative potential, leading to improved bone healing and defect repair. Similarly, in cartilage tissue engineering, silk fibroinbased hydrogels and scaffolds have shown promise in promoting chondrogenic differentiation of MSCs and supporting the formation of cartilage-like tissues [5]. The tunable mechanical properties and biocompatibility of silk fibroin allow for the development of scaffolds that mimic the viscoelasticity and biochemical composition of native cartilage, facilitating cell attachment, matrix production, and tissue integration. Additionally, the controlled release of growth factors or chondrogenic inducers from silk fibroin matrices further enhances cartilage regeneration and repair [6,7]. Silk fibroin-based biomaterials have also been investigated for tendon and ligament tissue engineering, where the hierarchical structure and mechanical properties of silk fibroin scaffolds closely resemble those of native tendon and ligament tissues [8]. Silk fibroin matrices provide a conducive environment for tenogenic differentiation of MSCs and the organization of collagen fibers, leading to the formation of functional tendon-like tissues. Moreover, the incorporation of growth factors or tenogenic inducers into silk fibroin scaffolds enhances tendon regeneration and improves mechanical strength and functionality [9,10].
Conclusion
Overall, silk fibroin-based biomaterials hold great promise for the treatment of musculoskeletal diseases, offering customizable scaffolds with tailored properties for promoting tissue regeneration and repair. Ongoing research efforts aimed at optimizing silk fibroin scaffold design, enhancing bioactivity, and elucidating their interactions with cells and tissues are essential for translating these innovations into effective clinical therapies. With continued advancements in silk fibroin-based biomaterials, regenerative medicine holds the potential to revolutionize the treatment of musculoskeletal disorders and improve patient outcomes.
References
- Halverson KM (2005) Anthrax biosensor, protective antigen ion channel asymmetric blockade. J Biol Chem 280:34056–62.
- Bayley H, Martin CR (2000) Resistive-pulse sensing – From microbes to molecules. Chem Rev 100:2575–94.
- Graham MD (2003). The Coulter principle: Foundation of an industry. J Lab Autom 8:72–81.
- Wang C, Zou P, Yang C, Liu L, Cheng L, et al. (2019). Dynamic modifications of biomacromolecules: mechanism and chemical interventions.Sci China Life Sci62: 1459-1471.
- Prosdocimi F, Farias ST, José MV (2022) Prebiotic chemical refugia: multifaceted scenario for the formation of biomolecules in primitive Earth.Theory Biosci141: 339-347.
- Wanunu M (2012) Nanopores: A journey towards DNA sequencing.Phys Life Rev 125-158.
- Hazen RM (2006). Mineral surfaces and the prebiotic selection and organization of biomolecules.Am Mineral 91: 1715.
- Vay LK, Mutschler H (2019) The difficult case of an RNA-only origin of life.Emerg Top Life Sci3: 469-475.
- Deblois RW, Bean CP, Wesley RKA (1977) Electrokinetic measurements with submicron particles and pores by resistive pulse technique. J Colloid Interface Sci 61:323–35.
- Kasianowicz JJ, Robertson JWF, Chan ER, Reiner JE, Stanford VM (2008). Annual review of analytical chemistry. Annual Reviews 1:737–66.
Indexed at, Coss ref , Google Scholar
Indexed at, Crossref, Google Scholar
Indexed at, Crossref, Google Scholar
Indexed at, Crossref, Google Scholar
Indexed at, Crossref, Google Scholar
Indexed at, Crossref, Google Scholar
Indexed at, Crossref, Google Scholar
Indexed at, Crossref, Google Scholar
Indexed at, Crossref, Google Scholar
Citation: Chowdhury R (2024) Biomaterial Based on Silk Fibroin for the treatmentof Musculoskeletal Diseases y. J Biotechnol Biomater, 14: 367.
Copyright: © 2024 Chowdhury R. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
Share This Article
Recommended Journals
Open Access Journals
Article Usage
- Total views: 128
- [From(publication date): 0-0 - Aug 16, 2024]
- Breakdown by view type
- HTML page views: 99
- PDF downloads: 29