Journal of Oncology Research and Treatment
Open Access

Dermatological oncology is a specialized field of medicine that focuses on the diagnosis, treatment, and management of skin cancer, a group of diseases that arise from the abnormal growth of cells in the skin. Skin cancer is the most common form of cancer globally, with its incidence steadily increasing over the past few decades. It poses a significant public health concern and has prompted extensive research and advancements in the field of dermatological oncology.

Skin cancer encompasses various subtypes, with the most common types being Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), and melanoma. BCC and SCC are known as Non-Melanoma Skin Cancers (NMSC), accounting for the majority of skin cancer cases. Melanoma, although less common, is the most advancing form and accounts for the majority of skin cancer-related deaths. Skin cancer is highly prevalent, with millions of cases diagnosed worldwide each year. The incidence varies geographically, with higher rates observed in regions with intense Ultraviolet (UV) radiation exposure, such as Australia and New Zealand. Additionally, fair-skinned individuals with a history of sunburns and prolonged sun exposure are at higher risk.

The major risk factor is exposure to UV radiation, either from the sun or artificial sources. Other risk factors include a family history of skin cancer, immunosuppression, chronic skin inflammation, exposure to certain chemicals or radiation, and a history of previous skin cancer. Early detection is crucial for successful treatment outcomes in skin cancer. Dermatological oncologists employ various diagnostic techniques to identify and stage skin cancer accurately. The primary tool for diagnosis is a skin biopsy, in which a small tissue sample is taken from the suspicious lesion and examined under a microscope. This helps determine the type of skin cancer and its stage, allowing the oncologist to plan the most appropriate treatment.

In addition to biopsies, dermatologists often use dermoscopy, a noninvasive imaging technique that allows them to visualize the skin's subsurface structures. Furthermore, advanced imaging techniques, such as confocal microscopy and Optical Coherence Tomography (OCT), have shown assuring results in aiding the diagnosis and assessment of skin cancer. Several treatment modalities are available, with the choice of treatment personalized to each individual case. Surgical excision is the standard treatment for localized skin cancer. To ensure thorough eradication, the malignant tissue must be removed together with a margin of good skin. In some cases, Mohs micrographic surgery may be used for certain high-risk or recurrent tumors, as it allows for precise removal of cancerous cells while sparing healthy tissue.

High-energy X-rays are used in radiation treatment to target and destroy cancer cells. It is often used as an adjuvant therapy after surgery or for patients who cannot undergo surgery. Certain superficial skin cancers or precancerous lesions can be treated with topical therapies such as imiquimod and 5-fluorouracil cream. This involves freezing the cancer cells with liquid nitrogen, which is commonly used for treating superficial skin lesions. This treatment involves the application of a photosensitizing agent followed by exposure to light, leading to the destruction of cancer cells. Immunotherapy drugs, such as immune checkpoint inhibitors, have shown remarkable success in treating advanced melanoma by enhancing the body's immune response against cancer cells. Targeted therapies specifically attack cancer cells with certain genetic mutations, offering a more personalized approach to treatment.

Over the years, significant advancements have been made in the field of dermatological oncology, revolutionizing skin cancer management and patient outcomes. Genetic and molecular studies have led to a better understanding of the underlying mechanisms driving skin cancer. This has prepare for personalized medicine approaches, where treatments can be tailored based on an individual's specific genetic profile. Advanced imaging techniques like confocal microscopy and OCT have enabled more accurate and non-invasive diagnosis of skin cancer, reducing the need for unnecessary biopsies. The development of immune checkpoint inhibitors and targeted therapies has transformed the treatment landscape for advanced melanoma and other aggressive skin cancers, significantly improving patient survival rates. Researchers are exploring the potential benefits of combining different treatment modalities, such as immunotherapy with targeted therapy or radiation, to enhance treatment efficacy and reduce the risk of resistance.

The advent of precision medicine, immunotherapies, and advanced imaging techniques has transformed the management of skin cancer, offering new hope to patients with advanced disease. Nevertheless, continued research, public education, and access to advanced therapies are vital to further improve outcomes and reduce the burden of skin cancer worldwide. Dermatological oncologists, working in collaboration with other healthcare professionals, continue to make strides in understanding and combatting this challenging group of diseases. Through ongoing efforts, it is hoped that dermatological oncology will continue to make significant contributions to cancer care and patient well-being.