Nonsteroidal Anti-inflammatory Drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs), including lowdose aspirin, are among the most widely prescribed medications, with approximately 30 million patients worldwide ingesting NSAID . NSAID could cause small intestinal injury. It became clear from the studies of post-mortem samplesby Bjarnason and colleagues (1993) that NSAID use is alsoassociated with significant damage to the more distal regionsof the small intestine (i.e. distal to the ligament of Treitz) . Small intestinal injury includes bleeding, erosion, and ulceration . Serious complications can includemassive bleeding, perforation and strictures, sometimes leading to death . PubMed with key words “NSAID and enteropathy” was used in 1994 through 2013 for selecting articles. The aim of this short review is to summarize out current understanding of NSAID induced small intestinal injury. NSAID can affect the jejunum and ileum . Capsule endoscopy (CE) and double-balloon endoscopy (DBE) are diagnostic methods for visualizing small intestinal lesions]. In the DBE group, out of 61 patients, ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively . In the cases indicated for enteroscopy, NSAIDs enteropathy occurred in half of the patients taking NSAIDs . Scientific journal is a periodical publication intended to further progress of science, usually by reporting novel research. There are thousands of scientific journals in publication, and many more have been published at various points in the past. Most journals are highly specialized, although some of the oldest journals publish articles and scientific papers across a wide range of scientific fields. Scientific journals contain articles that are peer reviewed, to ensure that articles meet the journal's standards of quality, and scientific validity. The publication of the results of research is an essential part of the scientific method. If they are describing experiments or calculations, they must supply enough details that an independent researcher could repeat the experiment or calculation to verify the results. Each such journal article becomes part of the permanent scientific record.

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Last date updated on December, 2024